DegronMD

Uniprot ID: Q8IVF5

Source protein: Rho guanine nucleotide exchange factor TIAM2

Source gene: TIAM2

Class: DEG_SCF_FBW7_2

Location: 147:154

E3 ligase: FBXW7

DEGRON score: 0.6869

ASA_SCORE: 73.8625

COIL: 0.8275

CONS_SCORE: 0.3238

DSS_SCORE: 0.5512

HELIX: 0.1003

FCONS_SCORE: 0.958

RIG_SCORE: 0.6443

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R156C	TCGA-4Z-AA82	BLCA	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.2778
p.R156C	DO218987	BLCA	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.2778
p.P152Q	TCGA-50-5930	LUAD	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.5924
p.P152Q	DO25189	LUAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.5924
p.G142R	TCGA-AC-A3OD	BRCA	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.1944
p.G142R	TCGA-CK-6746	COAD	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.1944
p.G142R	DO2365	BRCA	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.1944
p.G142R	DO7938	COAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.1944
p.R156H	TCGA-AZ-4315	COAD	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.2778
p.R156H	DO8842	COAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.2778
p.P152L	TCGA-BR-4368	STAD	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.6471
p.P152L	DO38715	STAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.6471
p.S149T	TCGA-EE-A29G	SKCM	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.7116
p.S149T	DO47303	SKCM	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.7116
p.G142W	TCGA-EE-A2MG	SKCM	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.1944
p.G142W	DO37421	SKCM	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.1944
p.G142E	TCGA-EO-A3B0	UCEC	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.1944
p.G142E	DO219773	UCEC	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.1944
p.R143K	TCGA-FG-A4MW	LGG	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.2222
p.R143K	DO44602	LGG	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.2222
p.K157N	TCGA-FR-A726	SKCM	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.3611
p.K157N	DO48665	SKCM	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.3611
p.S149F	TCGA-FW-A3R5	SKCM	TCGA	IASTPPGE	DEG_SCF_FBW7_2	0.7982
p.S149F	DO37406	SKCM	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.7982
p.D146E	DO10164	COAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.3056
p.T150A	DO234183	ESAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.825
p.G163V	DO22566	LGG	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.0833
p.R143M	DO228948	LICA	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.2222
p.P140S	DO49705	LIHC	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.1389
p.H142R	DO38380	STAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	0.1944
p.S146N	SIDM02021	Esophageal Carcinoma	GDSC	IASTPPGE	DEG_SCF_FBW7_2	0.3056
p.L162R	SIDM01064	Hodgkin's Lymphoma	GDSC	IASTPPGE	DEG_SCF_FBW7_2	0.1111
p.L137H	SIDM01042	Breast Carcinoma	GDSC	IASTPPGE	DEG_SCF_FBW7_2	0.0556
p.L137H	ACH-001065	Breast Cancer	CCLE	IASTPPGE	DEG_SCF_FBW7_2	0.0556
p.L137H	EVSA-T	breast	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	0.0556
p.V150F	ACH-000648	Lung Cancer	CCLE	IASTPPGE	DEG_SCF_FBW7_2	0.7068
p.V150F	NCI-H28	pleura	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	0.7068
p.R140Q	ACH-000666	Lung Cancer	CCLE	IASTPPGE	DEG_SCF_FBW7_2	0.1389
p.R140Q	NCI-H1355	lung	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	0.1389
p.P139T	NCI-H345	lung	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	0.1111
p.K160E	D-502MG	central_nervous_system	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	0.1667
p.S160N	MDA-MB-453	breast	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	0.1667
p.C152F	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	0.7108

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IASTPPGE

Degron related mutations and impact score

Drug responses associated with TIAM2 mutations

All proteins holding degron of IASTPPGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF5	Rho guanine nucleotide exchange factor TIAM2	DEG_SCF_FBW7_2	147:154	IASTPPGE	FBXW7	0.6869	More...