DegronMD - Q63ZY3(KANK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P68L	TCGA-23-1116	OV	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.6471
p.P68L	DO30050	OV	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.6471
p.P68L	SIDM00221	Melanoma	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.6471
p.P68L	ACH-002388	Skin Cancer	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.6471
p.D413N	TCGA-2F-A9KT	BLCA	TCGA	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.0556
p.D413N	DO51863	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.0556
p.S79F	TCGA-2W-A8YY	CESC	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1944
p.S79F	DO223732	CESC	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1944
p.V162L	TCGA-63-A5MJ	LUSC	TCGA	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.25
p.V162L	DO219149	LUSC	ICGC	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.25
p.V62M	TCGA-A5-A0G2	UCEC	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.2222
p.V62M	DO41235	UCEC	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.2222
p.L418P	TCGA-A7-A0CH	BRCA	TCGA	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1944
p.L418P	DO1872	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1944
p.S426F	TCGA-AX-A1CE	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.7982
p.S426F	DO42280	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.7982
p.P177L	TCGA-AX-A2HD	UCEC	TCGA	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.1944
p.P177L	TCGA-HQ-A5NE	BLCA	TCGA	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.1944
p.P177L	DO51900	BLCA	ICGC	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.1944
p.P177L	DO42608	UCEC	ICGC	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.1944
p.S427L	TCGA-B5-A3FC	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.7667
p.S427L	DO41871	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.7667
p.L73Q	TCGA-B9-5156	KIRP	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.7765
p.L73Q	DO20774	KIRP	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.7765
p.L59V	TCGA-BR-4361	STAD	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1389
p.L59V	DO38887	STAD	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1389
p.R493W	TCGA-D1-A167	UCEC	TCGA	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation blocking phosphorylation signal	0.7222
p.P500H	TCGA-D3-A2J6	SKCM	TCGA	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7694
p.P419T	TCGA-DU-7294	LGG	TCGA	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2222
p.P419T	DO22333	LGG	ICGC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2222
p.R61H	TCGA-EO-A3AZ	UCEC	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1944
p.R61H	DO50078	UCEC	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1944
p.R61C	TCGA-G4-6304	COAD	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1944
p.R61C	DO10639	COAD	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1944
p.P430L	TCGA-G4-6320	COAD	TCGA	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.P430L	DO8159	COAD	ICGC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.S432Y	TCGA-SX-A7SL	KIRP	TCGA	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1944
p.S432Y	DO49783	KIRP	ICGC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1944
p.P422L	DO48383	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.3056
p.T176I	DO222946	BTCA	ICGC	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation blocking phosphorylation signal	0.6667
p.G173R	DO6402	CLLE	ICGC	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.3056
p.A423V	DO230326	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.5825
p.R69C	DO234457	ESAD	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.719
p.R67H	DO233143	GACA	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.8244
p.R67H	SIDM02059	Colorectal Carcinoma	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.8244
p.T58K	DO229019	LICA	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation blocking phosphorylation signal	0.5556
p.R75S	DO229029	LICA	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.3056
p.N505K	DO229028	LICA	ICGC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.2778
p.S71R	DO229025	LICA	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.7427
p.S512F	DO50299	SKCM	ICGC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.0833
p.P492H	DO37901	SKCM	ICGC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.25
p.R485W	DO40978	UCEC	ICGC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.0556
p.E513K	DO42608	UCEC	ICGC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.0556
p.A502V	SIDM01293	Colorectal Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.6936
p.E495V	SIDM00629	Breast Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7693
p.E495V	ACH-000573	Breast Cancer	CCLE	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7693
p.E495V	MDA-MB-436	breast	COSMIC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7693
p.A498T	SIDM01265	Plasma Cell Myeloma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00967	Ovarian Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM01117	Small Cell Lung Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00656	Burkitt's Lymphoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM01112	Osteosarcoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00879	Breast Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00844	Burkitt's Lymphoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00907	Burkitt's Lymphoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM01147	Gastric Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00882	Breast Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00068	Colorectal Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00720	Mesothelioma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00628	Breast Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.A498T	SIDM00641	Burkitt's Lymphoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7139
p.S425L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation altering degron motif	0.8778
p.P430T	SIDM01017	B-Lymphoblastic Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.P430T	ACH-002255	Lymphoma	CCLE	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.P430T	KARPAS-231	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.25
p.V510M	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.1389
p.V510M	SIDM01566	Hodgkin's Lymphoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.1389
p.Q65K	SIDM00364	B-Lymphoblastic Leukemia	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.3056
p.Q65K	ACH-002059	Leukemia	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.3056
p.Q65K	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.3056
p.T82M	SIDM01113	Other Sarcomas	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1111
p.T82M	ACH-000939	Sarcoma	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1111
p.T82M	SK-UT-1	soft tissue	COSMIC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1111
p.L418I	SIDM00596	Endometrial Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1944
p.L418I	ACH-001517	Endometrial/Uterine Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1944
p.L418I	HEC-1	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.1944
p.A182T	SIDM00292	Small Cell Lung Carcinoma	GDSC	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.0556
p.A182T	LU-165	lung	COSMIC	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.0556
p.G173E	SIDM00292	Small Cell Lung Carcinoma	GDSC	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.3056
p.G173E	LU-165	lung	COSMIC	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation rewiring degron network	0.3056
p.T58M	SIDM01146	Gastric Carcinoma	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation blocking phosphorylation signal	0.5556
p.T58M	ACH-000932	Gastric Cancer	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation blocking phosphorylation signal	0.5556
p.T58M	NCI-SNU-1	stomach	COSMIC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation blocking phosphorylation signal	0.5556
p.R66H	SIDM01617	Endometrial Carcinoma	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.7133
p.R66H	ACH-000994	Endometrial/Uterine Cancer	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.7133
p.S506I	SIDM01469	Pancreatic Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.25
p.R493Q	SIDM01518	Oral Cavity Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation blocking phosphorylation signal	0.7222
p.S498I	ACH-000085	Pancreatic Cancer	CCLE	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.623
p.V64M	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.2778
p.R493L	ACH-000975	Lung Cancer	CCLE	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation blocking phosphorylation signal	0.7222
p.G431R	ACH-001100		CCLE	AESSS	DEG_SPOP_SBC_1	423:427	Mutation rewiring degron network	0.2222
p.P166L	ACH-002396	Bone Cancer	CCLE	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation altering degron motif	0.6471
p.P166L	Sarc9371	bone	COSMIC	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation altering degron motif	0.6471
p.S158F	ACH-002669	Colon/Colorectal Cancer	CCLE	PPPTPRSS	DEG_SCF_FBW7_1	165:172	Mutation blocking phosphorylation signal	0.5833
p.S510L	NKM-1	haematopoietic and lymphoid tissue	COSMIC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.1389
p.E487V	MDA-MB-436	breast	COSMIC	HRRSLQFVG	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KANK2

UniProt ID: Q63ZY3

Entrez ID: 25959

Protein name: KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KANK2 in