DegronMD

Uniprot ID: Q63ZY3

Source protein: KN motif and ankyrin repeat domain-containing protein 2

Source gene: KANK2

Class: DEG_APCC_DBOX_1

Location: 495:503

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.762

ASA_SCORE: 79.2111

COIL: 0.4952

CONS_SCORE: 0.3477

DSS_SCORE: 0.5639

HELIX: 0.1438

FCONS_SCORE: 0.8632

RIG_SCORE: 0.7545

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R493W	TCGA-D1-A167	UCEC	TCGA	HRRSLQFVG	DEG_APCC_DBOX_1	0.7222
p.P500H	TCGA-D3-A2J6	SKCM	TCGA	HRRSLQFVG	DEG_APCC_DBOX_1	0.7694
p.N505K	DO229028	LICA	ICGC	HRRSLQFVG	DEG_APCC_DBOX_1	0.2778
p.S512F	DO50299	SKCM	ICGC	HRRSLQFVG	DEG_APCC_DBOX_1	0.0833
p.P492H	DO37901	SKCM	ICGC	HRRSLQFVG	DEG_APCC_DBOX_1	0.25
p.R485W	DO40978	UCEC	ICGC	HRRSLQFVG	DEG_APCC_DBOX_1	0.0556
p.E513K	DO42608	UCEC	ICGC	HRRSLQFVG	DEG_APCC_DBOX_1	0.0556
p.A502V	SIDM01293	Colorectal Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.6936
p.E495V	SIDM00629	Breast Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7693
p.E495V	ACH-000573	Breast Cancer	CCLE	HRRSLQFVG	DEG_APCC_DBOX_1	0.7693
p.E495V	MDA-MB-436	breast	COSMIC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7693
p.A498T	SIDM01265	Plasma Cell Myeloma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00967	Ovarian Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM01117	Small Cell Lung Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00656	Burkitt's Lymphoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM01112	Osteosarcoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00879	Breast Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00844	Burkitt's Lymphoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00907	Burkitt's Lymphoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM01147	Gastric Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00882	Breast Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00068	Colorectal Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00720	Mesothelioma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00628	Breast Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.A498T	SIDM00641	Burkitt's Lymphoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7139
p.V510M	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.1389
p.V510M	SIDM01566	Hodgkin's Lymphoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.1389
p.S506I	SIDM01469	Pancreatic Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.25
p.R493Q	SIDM01518	Oral Cavity Carcinoma	GDSC	HRRSLQFVG	DEG_APCC_DBOX_1	0.7222
p.S498I	ACH-000085	Pancreatic Cancer	CCLE	HRRSLQFVG	DEG_APCC_DBOX_1	0.623
p.R493L	ACH-000975	Lung Cancer	CCLE	HRRSLQFVG	DEG_APCC_DBOX_1	0.7222
p.S510L	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	HRRSLQFVG	DEG_APCC_DBOX_1	0.1389
p.E487V	MDA-MB-436	breast	COSMIC	HRRSLQFVG	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HRRSLQFVG

Degron related mutations and impact score

Drug responses associated with KANK2 mutations

All proteins holding degron of HRRSLQFVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q63ZY3	KN motif and ankyrin repeat domain-containing protein 2	DEG_APCC_DBOX_1	495:503	HRRSLQFVG	APC,CDC20,FZR1	0.762	More...