DegronMD

Uniprot ID: Q63ZY3

Source protein: KN motif and ankyrin repeat domain-containing protein 2

Source gene: KANK2

Class: DEG_SCF_FBW7_1

Location: 165:172

E3 ligase: FBXW7

DEGRON score: 0.9874

ASA_SCORE: 90.2

COIL: 0.9454

CONS_SCORE: 0.3849

DSS_SCORE: 0.624

HELIX: 0.021

FCONS_SCORE: 0.8692

RIG_SCORE: 0.5838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V162L	TCGA-63-A5MJ	LUSC	TCGA	PPPTPRSS	DEG_SCF_FBW7_1	0.25
p.V162L	DO219149	LUSC	ICGC	PPPTPRSS	DEG_SCF_FBW7_1	0.25
p.P177L	TCGA-AX-A2HD	UCEC	TCGA	PPPTPRSS	DEG_SCF_FBW7_1	0.1944
p.P177L	TCGA-HQ-A5NE	BLCA	TCGA	PPPTPRSS	DEG_SCF_FBW7_1	0.1944
p.P177L	DO51900	BLCA	ICGC	PPPTPRSS	DEG_SCF_FBW7_1	0.1944
p.P177L	DO42608	UCEC	ICGC	PPPTPRSS	DEG_SCF_FBW7_1	0.1944
p.T176I	DO222946	BTCA	ICGC	PPPTPRSS	DEG_SCF_FBW7_1	0.6667
p.G173R	DO6402	CLLE	ICGC	PPPTPRSS	DEG_SCF_FBW7_1	0.3056
p.A182T	SIDM00292	Small Cell Lung Carcinoma	GDSC	PPPTPRSS	DEG_SCF_FBW7_1	0.0556
p.A182T	LU-165	lung	COSMIC	PPPTPRSS	DEG_SCF_FBW7_1	0.0556
p.G173E	SIDM00292	Small Cell Lung Carcinoma	GDSC	PPPTPRSS	DEG_SCF_FBW7_1	0.3056
p.G173E	LU-165	lung	COSMIC	PPPTPRSS	DEG_SCF_FBW7_1	0.3056
p.P166L	ACH-002396	Bone Cancer	CCLE	PPPTPRSS	DEG_SCF_FBW7_1	0.6471
p.P166L	Sarc9371	bone	COSMIC	PPPTPRSS	DEG_SCF_FBW7_1	0.6471
p.S158F	ACH-002669	Colon/Colorectal Cancer	CCLE	PPPTPRSS	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q63ZY3	KN motif and ankyrin repeat domain-containing protein 2	DEG_SCF_FBW7_1	165:172	PPPTPRSS	FBXW7	0.9874	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons