DegronMD

Uniprot ID: Q63ZY3

Source protein: KN motif and ankyrin repeat domain-containing protein 2

Source gene: KANK2

Class: DEG_APCC_DBOX_1

Location: 66:74

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9947

ASA_SCORE: 110.3111

COIL: 0.9096

CONS_SCORE: 0.4392

DSS_SCORE: 0.3931

HELIX: 0.0719

FCONS_SCORE: 1.0256

RIG_SCORE: 0.7182

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P68L	TCGA-23-1116	OV	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	0.6471
p.P68L	DO30050	OV	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.6471
p.P68L	SIDM00221	Melanoma	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	0.6471
p.P68L	ACH-002388	Skin Cancer	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	0.6471
p.S79F	TCGA-2W-A8YY	CESC	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	0.1944
p.S79F	DO223732	CESC	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.1944
p.V62M	TCGA-A5-A0G2	UCEC	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	0.2222
p.V62M	DO41235	UCEC	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.2222
p.L73Q	TCGA-B9-5156	KIRP	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	0.7765
p.L73Q	DO20774	KIRP	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.7765
p.L59V	TCGA-BR-4361	STAD	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	0.1389
p.L59V	DO38887	STAD	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.1389
p.R61H	TCGA-EO-A3AZ	UCEC	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	0.1944
p.R61H	DO50078	UCEC	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.1944
p.R61C	TCGA-G4-6304	COAD	TCGA	RRPRLSSLP	DEG_APCC_DBOX_1	0.1944
p.R61C	DO10639	COAD	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.1944
p.R69C	DO234457	ESAD	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.719
p.R67H	DO233143	GACA	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.8244
p.R67H	SIDM02059	Colorectal Carcinoma	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	0.8244
p.T58K	DO229019	LICA	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.5556
p.R75S	DO229029	LICA	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.3056
p.S71R	DO229025	LICA	ICGC	RRPRLSSLP	DEG_APCC_DBOX_1	0.7427
p.Q65K	SIDM00364	B-Lymphoblastic Leukemia	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	0.3056
p.Q65K	ACH-002059	Leukemia	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	0.3056
p.Q65K	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	RRPRLSSLP	DEG_APCC_DBOX_1	0.3056
p.T82M	SIDM01113	Other Sarcomas	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	0.1111
p.T82M	ACH-000939	Sarcoma	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	0.1111
p.T82M	SK-UT-1	soft_tissue	COSMIC	RRPRLSSLP	DEG_APCC_DBOX_1	0.1111
p.T58M	SIDM01146	Gastric Carcinoma	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	0.5556
p.T58M	ACH-000932	Gastric Cancer	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	0.5556
p.T58M	NCI-SNU-1	stomach	COSMIC	RRPRLSSLP	DEG_APCC_DBOX_1	0.5556
p.R66H	SIDM01617	Endometrial Carcinoma	GDSC	RRPRLSSLP	DEG_APCC_DBOX_1	0.7133
p.R66H	ACH-000994	Endometrial/Uterine Cancer	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	0.7133
p.V64M	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRPRLSSLP	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRPRLSSLP

Degron related mutations and impact score

Drug responses associated with KANK2 mutations

All proteins holding degron of RRPRLSSLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q63ZY3	KN motif and ankyrin repeat domain-containing protein 2	DEG_APCC_DBOX_1	66:74	RRPRLSSLP	APC,CDC20,FZR1	0.9947	More...