DegronMD - Q9UL62(TRPC5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S122R	TCGA-17-Z062	LUAD	TCGA	SGEKQVPTL	DEG_COP1_1	122:130	Mutation altering degron motif	0.7427
p.Y118S	TCGA-22-1005	LUSC	TCGA	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2222
p.Y118S	DO26632	LUSC	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2222
p.F837L	TCGA-56-7822	LUSC	TCGA	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.2222
p.F837L	DO26638	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.2222
p.S836C	TCGA-75-5122	LUAD	TCGA	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.25
p.S836C	DO23882	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.25
p.R120P	TCGA-78-7155	LUAD	TCGA	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2778
p.R120P	DO23590	LUAD	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2778
p.T134M	TCGA-85-8071	LUSC	TCGA	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2222
p.T134M	DO26755	LUSC	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2222
p.T134S	TCGA-91-A4BC	LUAD	TCGA	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2222
p.T134S	DO45422	LUAD	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2222
p.Q126H	TCGA-98-A53H	LUSC	TCGA	SGEKQVPTL	DEG_COP1_1	122:130	Mutation altering degron motif	0.647
p.Q126H	DO219181	LUSC	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation altering degron motif	0.647
p.R120W	TCGA-A5-A0G2	UCEC	TCGA	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2778
p.R120W	DO41235	UCEC	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2778
p.R120W	SIDM02073	Colorectal Carcinoma	GDSC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2778
p.K843N	TCGA-AP-A1E0	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	829:833	Mutation substituting flanking lysine	0.1667
p.K843N	TCGA-AX-A0J0	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	829:833	Mutation substituting flanking lysine	0.1667
p.K843N	DO43154	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	829:833	Mutation substituting flanking lysine	0.1667
p.K843N	DO41133	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	829:833	Mutation substituting flanking lysine	0.1667
p.S820F	TCGA-CD-A48A	STAD	TCGA	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.S820F	TCGA-D1-A2G0	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.S820F	DO47781	STAD	ICGC	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.S820F	DO43049	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.S841F	TCGA-D3-A51T	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.1111
p.S841F	DO47389	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.1111
p.E113Q	TCGA-VS-A9UA	CESC	TCGA	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.0833
p.E113Q	DO219730	CESC	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.0833
p.F136L	DO8264	COAD	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1667
p.Q126K	DO229027	LICA	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation altering degron motif	0.5833
p.Q135K	DO229026	LICA	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1944
p.G123R	DO220851	MELA	ICGC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation altering degron motif	0.6457
p.G123R	SIDM00336	Melanoma	GDSC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation altering degron motif	0.6457
p.G123R	ACH-000881	Skin Cancer	CCLE	SGEKQVPTL	DEG_COP1_1	122:130	Mutation altering degron motif	0.6457
p.G123R	MEL-JUSO	skin	COSMIC	SGEKQVPTL	DEG_COP1_1	122:130	Mutation altering degron motif	0.6457
p.R819M	SIDM00148	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0556
p.R819M	ACH-000019	Breast Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0556
p.R819M	MCF7	breast	COSMIC	AESSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0556
p.D133G	ACH-001413	Bladder Cancer	CCLE	SGEKQVPTL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.25

Kaplan plot for TRPC5 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRPC5

UniProt ID: Q9UL62

Entrez ID: 7224

Protein name: Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TRPC5 in