DegronMD

Uniprot ID: Q9UL62

Source protein: Short transient receptor potential channel 5

Source gene: TRPC5

Class: DEG_COP1_1

Location: 122:130

E3 ligase: COP1

DEGRON score: 0.5892

ASA_SCORE: 77.9556

COIL: 0.7157

CONS_SCORE: 0.4398

DSS_SCORE: 0.3498

HELIX: 0.0878

FCONS_SCORE: 0.8597

RIG_SCORE: 0.7419

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S122R	TCGA-17-Z062	LUAD	TCGA	SGEKQVPTL	DEG_COP1_1	0.7427
p.Y118S	TCGA-22-1005	LUSC	TCGA	SGEKQVPTL	DEG_COP1_1	0.2222
p.Y118S	DO26632	LUSC	ICGC	SGEKQVPTL	DEG_COP1_1	0.2222
p.R120P	TCGA-78-7155	LUAD	TCGA	SGEKQVPTL	DEG_COP1_1	0.2778
p.R120P	DO23590	LUAD	ICGC	SGEKQVPTL	DEG_COP1_1	0.2778
p.T134M	TCGA-85-8071	LUSC	TCGA	SGEKQVPTL	DEG_COP1_1	0.2222
p.T134M	DO26755	LUSC	ICGC	SGEKQVPTL	DEG_COP1_1	0.2222
p.T134S	TCGA-91-A4BC	LUAD	TCGA	SGEKQVPTL	DEG_COP1_1	0.2222
p.T134S	DO45422	LUAD	ICGC	SGEKQVPTL	DEG_COP1_1	0.2222
p.Q126H	TCGA-98-A53H	LUSC	TCGA	SGEKQVPTL	DEG_COP1_1	0.647
p.Q126H	DO219181	LUSC	ICGC	SGEKQVPTL	DEG_COP1_1	0.647
p.R120W	TCGA-A5-A0G2	UCEC	TCGA	SGEKQVPTL	DEG_COP1_1	0.2778
p.R120W	DO41235	UCEC	ICGC	SGEKQVPTL	DEG_COP1_1	0.2778
p.R120W	SIDM02073	Colorectal Carcinoma	GDSC	SGEKQVPTL	DEG_COP1_1	0.2778
p.E113Q	TCGA-VS-A9UA	CESC	TCGA	SGEKQVPTL	DEG_COP1_1	0.0833
p.E113Q	DO219730	CESC	ICGC	SGEKQVPTL	DEG_COP1_1	0.0833
p.F136L	DO8264	COAD	ICGC	SGEKQVPTL	DEG_COP1_1	0.1667
p.Q126K	DO229027	LICA	ICGC	SGEKQVPTL	DEG_COP1_1	0.5833
p.Q135K	DO229026	LICA	ICGC	SGEKQVPTL	DEG_COP1_1	0.1944
p.G123R	DO220851	MELA	ICGC	SGEKQVPTL	DEG_COP1_1	0.6457
p.G123R	SIDM00336	Melanoma	GDSC	SGEKQVPTL	DEG_COP1_1	0.6457
p.G123R	ACH-000881	Skin Cancer	CCLE	SGEKQVPTL	DEG_COP1_1	0.6457
p.G123R	MEL-JUSO	skin	COSMIC	SGEKQVPTL	DEG_COP1_1	0.6457
p.D133G	ACH-001413	Bladder Cancer	CCLE	SGEKQVPTL	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UL62	Short transient receptor potential channel 5	DEG_COP1_1	122:130	SGEKQVPTL	COP1	0.5892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons