DegronMD - Q9H4L7(SMARCAD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T63S	TCGA-19-5956	GBM	TCGA	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation blocking phosphorylation signal	0.6389
p.T63S	DO13863	GBM	ICGC	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation blocking phosphorylation signal	0.6389
p.D365H	TCGA-77-7338	LUSC	TCGA	DYSSGE	DEG_Kelch_Keap1_1	373:378	Mutation rewiring degron network	0.1111
p.D365H	DO26421	LUSC	ICGC	DYSSGE	DEG_Kelch_Keap1_1	373:378	Mutation rewiring degron network	0.1111
p.S744L	TCGA-A5-A2K5	UCEC	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6556
p.S744L	TCGA-CG-5728	STAD	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6556
p.S744L	SIDM00193	Colorectal Carcinoma	GDSC	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6556
p.S744L	SNU-81	large intestine	COSMIC	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6556
p.P21A	TCGA-AA-3984	COAD	TCGA	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.7503
p.P21A	DO9002	COAD	ICGC	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.7503
p.L754I	TCGA-AA-A010	COAD	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.L754I	TCGA-AZ-4315	COAD	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.L754I	DO8842	COAD	ICGC	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.R737Q	TCGA-AG-3892	READ	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7329
p.R737Q	DO36394	READ	ICGC	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7329
p.L740S	TCGA-BS-A0UV	UCEC	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7667
p.L728V	TCGA-C5-A2LX	CESC	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1111
p.L728V	DO49004	CESC	ICGC	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1111
p.G236E	TCGA-C8-A8HP	BRCA	TCGA	AESSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1389
p.G236E	DO219621	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1389
p.S245Y	TCGA-CA-6717	COAD	TCGA	AESSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.8231
p.S245Y	DO8264	COAD	ICGC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.8231
p.K388T	TCGA-CA-6718	COAD	TCGA	DYSSGE	DEG_Kelch_Keap1_1	373:378	Mutation blocking ubiquitination signal	0.5
p.K388T	DO7801	COAD	ICGC	DYSSGE	DEG_Kelch_Keap1_1	373:378	Mutation blocking ubiquitination signal	0.5
p.E378K	TCGA-DR-A0ZM	CESC	TCGA	DYSSGE	DEG_Kelch_Keap1_1	373:378	Mutation altering degron motif	0.7022
p.E378K	DO6254	CESC	ICGC	DYSSGE	DEG_Kelch_Keap1_1	373:378	Mutation altering degron motif	0.7022
p.P69A	TCGA-DS-A1OA	CESC	TCGA	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation altering degron motif	0.6392
p.P69A	DO6341	CESC	ICGC	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation altering degron motif	0.6392
p.S66F	TCGA-EY-A1GI	UCEC	TCGA	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation blocking phosphorylation signal	0.7222
p.S66F	DO41211	UCEC	ICGC	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation blocking phosphorylation signal	0.7222
p.A20V	TCGA-F1-A448	STAD	TCGA	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.3056
p.A20V	DO48044	STAD	ICGC	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.3056
p.S28A	TCGA-G4-6625	COAD	TCGA	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.7588
p.S28A	DO9266	COAD	ICGC	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.7588
p.K734N	TCGA-VS-AA62	CESC	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.2778
p.Q71E	DO49753	BLCA	ICGC	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation altering degron motif	0.6744
p.S371P	DO10324	COAD	ICGC	DYSSGE	DEG_Kelch_Keap1_1	373:378	Mutation rewiring degron network	0.2778
p.S371P	DO8264	COAD	ICGC	DYSSGE	DEG_Kelch_Keap1_1	373:378	Mutation rewiring degron network	0.2778
p.S247N	DO229013	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7069
p.S247N	DO229016	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7069
p.S247N	DO229005	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7069
p.S247N	DO230968	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7069
p.E64D	DO233145	GACA	ICGC	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation rewiring degron network	0.2222
p.E382K	DO233908	GACA	ICGC	DYSSGE	DEG_Kelch_Keap1_1	373:378	Mutation rewiring degron network	0.2222
p.K83R	DO20942	KIRP	ICGC	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation rewiring degron network	0.1111
p.K16T	DO232026	LICA	ICGC	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation substituting flanking lysine	0.3056
p.G74C	DO229018	LICA	ICGC	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation altering degron motif	0.76
p.A243S	DO229018	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7588
p.W77L	DO229026	LICA	ICGC	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation blocking ubiquitination signal	0.7222
p.A243T	DO232842	NACA	ICGC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7139
p.L373R	DO52412	UCEC	ICGC	DYSSGE	DEG_Kelch_Keap1_1	373:378	Mutation altering degron motif	0.8428
p.N233T	DO42673	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0556
p.N15S	SIDM00845	Burkitt's Lymphoma	GDSC	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.1667
p.D65Y	SIDM00500	Colorectal Carcinoma	GDSC	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation rewiring degron network	0.25
p.D65Y	ACH-000959	Colon/Colorectal Cancer	CCLE	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation rewiring degron network	0.25
p.W13R	ACH-000545	Bladder Cancer	CCLE	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation substituting flanking lysine	0.2222
p.W13R	VM-CUB-1	urinary tract	COSMIC	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation substituting flanking lysine	0.2222
p.S36L	ACH-000641	Leukemia	CCLE	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.1111
p.S36L	ACH-001036	Leukemia	CCLE	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.1111
p.S36L	CMK	haematopoietic and lymphoid tissue	COSMIC	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.1111
p.V24I	ACH-000998	Colon/Colorectal Cancer	CCLE	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.7076
p.V24I	CW-2	large intestine	COSMIC	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.7076
p.S239L	ACH-001002	Skin Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	243:247	Mutation blocking phosphorylation signal	0.6667
p.S239L	451Lu	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation blocking phosphorylation signal	0.6667
p.Y70S	ACH-001134	Lymphoma	CCLE	VPETPDNE	DEG_SCF_FBW7_2	68:75	Mutation altering degron motif	0.712
p.S252I	ACH-001331	Head and Neck Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1944
p.S252I	BICR10	upper aerodigestive tract	COSMIC	AESSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1944
p.I26V	ACH-001605	Brain Cancer	CCLE	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.7076
p.I26V	no-10	central nervous system	COSMIC	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.7076
p.K251N	ACH-001624	Brain Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	243:247	Mutation substituting flanking lysine	0.3333
p.L11F	ACH-002163	Breast Cancer	CCLE	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.0556
p.L11F	MRK-nu-1	breast	COSMIC	PEATPQPS	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMARCAD1

UniProt ID: Q9H4L7

Entrez ID: 56916

Protein name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMARCAD1 in