DegronMD

Uniprot ID: Q9H4L7

Source protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

Source gene: SMARCAD1

Class: DEG_APCC_DBOX_1

Location: 736:744

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8533

ASA_SCORE: 57.2222

COIL: 0.3622

CONS_SCORE: 0.4726

DSS_SCORE: 0.298

HELIX: 0.0044

FCONS_SCORE: 0.893

RIG_SCORE: 0.843

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S744L	TCGA-A5-A2K5	UCEC	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	0.6556
p.S744L	TCGA-CG-5728	STAD	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	0.6556
p.S744L	SIDM00193	Colorectal Carcinoma	GDSC	DRIELCAMS	DEG_APCC_DBOX_1	0.6556
p.S744L	SNU-81	large_intestine	COSMIC	DRIELCAMS	DEG_APCC_DBOX_1	0.6556
p.L754I	TCGA-AA-A010	COAD	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	0.0556
p.L754I	TCGA-AZ-4315	COAD	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	0.0556
p.L754I	DO8842	COAD	ICGC	DRIELCAMS	DEG_APCC_DBOX_1	0.0556
p.R737Q	TCGA-AG-3892	READ	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	0.7329
p.R737Q	DO36394	READ	ICGC	DRIELCAMS	DEG_APCC_DBOX_1	0.7329
p.L740S	TCGA-BS-A0UV	UCEC	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	0.7667
p.L728V	TCGA-C5-A2LX	CESC	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	0.1111
p.L728V	DO49004	CESC	ICGC	DRIELCAMS	DEG_APCC_DBOX_1	0.1111
p.K734N	TCGA-VS-AA62	CESC	TCGA	DRIELCAMS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4L7	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	DEG_APCC_DBOX_1	736:744	DRIELCAMS	APC,CDC20,FZR1	0.8533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons