DegronMD

Uniprot ID: Q9H4L7

Source protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

Source gene: SMARCAD1

Class: DEG_Kelch_Keap1_1

Location: 373:378

E3 ligase: KEAP1

DEGRON score: 0.861

ASA_SCORE: 85.3333

COIL: 0.8135

CONS_SCORE: 0.2803

DSS_SCORE: 0.5748

HELIX: 0.155

FCONS_SCORE: 1.0305

RIG_SCORE: 0.6891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D365H	TCGA-77-7338	LUSC	TCGA	DYSSGE	DEG_Kelch_Keap1_1	0.1111
p.D365H	DO26421	LUSC	ICGC	DYSSGE	DEG_Kelch_Keap1_1	0.1111
p.K388T	TCGA-CA-6718	COAD	TCGA	DYSSGE	DEG_Kelch_Keap1_1	0.5
p.K388T	DO7801	COAD	ICGC	DYSSGE	DEG_Kelch_Keap1_1	0.5
p.E378K	TCGA-DR-A0ZM	CESC	TCGA	DYSSGE	DEG_Kelch_Keap1_1	0.7022
p.E378K	DO6254	CESC	ICGC	DYSSGE	DEG_Kelch_Keap1_1	0.7022
p.S371P	DO10324	COAD	ICGC	DYSSGE	DEG_Kelch_Keap1_1	0.2778
p.S371P	DO8264	COAD	ICGC	DYSSGE	DEG_Kelch_Keap1_1	0.2778
p.E382K	DO233908	GACA	ICGC	DYSSGE	DEG_Kelch_Keap1_1	0.2222
p.L373R	DO52412	UCEC	ICGC	DYSSGE	DEG_Kelch_Keap1_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4L7	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	DEG_Kelch_Keap1_1	373:378	DYSSGE	KEAP1	0.861	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons