DegronMD

Uniprot ID: Q9H4L7

Source protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

Source gene: SMARCAD1

Class: DEG_SCF_FBW7_1

Location: 21:28

E3 ligase: FBXW7

DEGRON score: 0.9868

ASA_SCORE: 101.9625

COIL: 0.9674

CONS_SCORE: 0.1796

DSS_SCORE: 0.8282

HELIX: 0.0176

FCONS_SCORE: 0.7459

RIG_SCORE: 0.5756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P21A	TCGA-AA-3984	COAD	TCGA	PEATPQPS	DEG_SCF_FBW7_1	0.7503
p.P21A	DO9002	COAD	ICGC	PEATPQPS	DEG_SCF_FBW7_1	0.7503
p.A20V	TCGA-F1-A448	STAD	TCGA	PEATPQPS	DEG_SCF_FBW7_1	0.3056
p.A20V	DO48044	STAD	ICGC	PEATPQPS	DEG_SCF_FBW7_1	0.3056
p.S28A	TCGA-G4-6625	COAD	TCGA	PEATPQPS	DEG_SCF_FBW7_1	0.7588
p.S28A	DO9266	COAD	ICGC	PEATPQPS	DEG_SCF_FBW7_1	0.7588
p.K16T	DO232026	LICA	ICGC	PEATPQPS	DEG_SCF_FBW7_1	0.3056
p.N15S	SIDM00845	Burkitt's Lymphoma	GDSC	PEATPQPS	DEG_SCF_FBW7_1	0.1667
p.W13R	ACH-000545	Bladder Cancer	CCLE	PEATPQPS	DEG_SCF_FBW7_1	0.2222
p.W13R	VM-CUB-1	urinary_tract	COSMIC	PEATPQPS	DEG_SCF_FBW7_1	0.2222
p.S36L	ACH-000641	Leukemia	CCLE	PEATPQPS	DEG_SCF_FBW7_1	0.1111
p.S36L	ACH-001036	Leukemia	CCLE	PEATPQPS	DEG_SCF_FBW7_1	0.1111
p.S36L	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PEATPQPS	DEG_SCF_FBW7_1	0.1111
p.V24I	ACH-000998	Colon/Colorectal Cancer	CCLE	PEATPQPS	DEG_SCF_FBW7_1	0.7076
p.V24I	CW-2	large_intestine	COSMIC	PEATPQPS	DEG_SCF_FBW7_1	0.7076
p.I26V	ACH-001605	Brain Cancer	CCLE	PEATPQPS	DEG_SCF_FBW7_1	0.7076
p.I26V	no-10	central_nervous_system	COSMIC	PEATPQPS	DEG_SCF_FBW7_1	0.7076
p.L11F	ACH-002163	Breast Cancer	CCLE	PEATPQPS	DEG_SCF_FBW7_1	0.0556
p.L11F	MRK-nu-1	breast	COSMIC	PEATPQPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4L7	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	DEG_SCF_FBW7_1	21:28	PEATPQPS	FBXW7	0.9868	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons