DegronMD

Uniprot ID: Q9H4L7

Source protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

Source gene: SMARCAD1

Class: DEG_SCF_FBW7_2

Location: 68:75

E3 ligase: FBXW7

DEGRON score: 0.5544

ASA_SCORE: 93.775

COIL: 0.8623

CONS_SCORE: 0.2385

DSS_SCORE: 0.664

HELIX: 0.1178

FCONS_SCORE: 0.9244

RIG_SCORE: 0.6594

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T63S	TCGA-19-5956	GBM	TCGA	VPETPDNE	DEG_SCF_FBW7_2	0.6389
p.T63S	DO13863	GBM	ICGC	VPETPDNE	DEG_SCF_FBW7_2	0.6389
p.P69A	TCGA-DS-A1OA	CESC	TCGA	VPETPDNE	DEG_SCF_FBW7_2	0.6392
p.P69A	DO6341	CESC	ICGC	VPETPDNE	DEG_SCF_FBW7_2	0.6392
p.S66F	TCGA-EY-A1GI	UCEC	TCGA	VPETPDNE	DEG_SCF_FBW7_2	0.7222
p.S66F	DO41211	UCEC	ICGC	VPETPDNE	DEG_SCF_FBW7_2	0.7222
p.Q71E	DO49753	BLCA	ICGC	VPETPDNE	DEG_SCF_FBW7_2	0.6744
p.E64D	DO233145	GACA	ICGC	VPETPDNE	DEG_SCF_FBW7_2	0.2222
p.K83R	DO20942	KIRP	ICGC	VPETPDNE	DEG_SCF_FBW7_2	0.1111
p.G74C	DO229018	LICA	ICGC	VPETPDNE	DEG_SCF_FBW7_2	0.76
p.W77L	DO229026	LICA	ICGC	VPETPDNE	DEG_SCF_FBW7_2	0.7222
p.D65Y	SIDM00500	Colorectal Carcinoma	GDSC	VPETPDNE	DEG_SCF_FBW7_2	0.25
p.D65Y	ACH-000959	Colon/Colorectal Cancer	CCLE	VPETPDNE	DEG_SCF_FBW7_2	0.25
p.Y70S	ACH-001134	Lymphoma	CCLE	VPETPDNE	DEG_SCF_FBW7_2	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4L7	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	DEG_SCF_FBW7_2	68:75	VPETPDNE	FBXW7	0.5544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons