DegronMD - P21127(CDK11B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A390V	TCGA-AP-A0LM	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.1389
p.D368N	TCGA-CG-5721	STAD	TCGA	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D368N	TCGA-EY-A1GI	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.E383D	TCGA-D3-A2J6	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation altering degron motif	0.6758
p.R369L	TCGA-DD-AADE	LIHC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0833
p.E393D	TCGA-EE-A17Y	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.P386S	TCGA-FS-A1ZK	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.25
p.G384A	TCGA-L5-A43C	ESCA	TCGA	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation blocking phosphorylation signal	0.75
p.D393N	DO224726	COCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	DO222860	COCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	DO222829	COCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	DO222856	COCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	DO231108	LAML	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	DO229257	THCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	DO229213	THCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	OC-314	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	IGROV-1	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	IST-MEL1	skin	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	PANC-03-27	pancreas	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.D393N	KNS-42	central nervous system	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0556
p.S376R	DO229045	LICA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.2778
p.P384S	DO37474	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation blocking phosphorylation signal	0.75
p.E391D	DO47459	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.1111
p.E381D	DO37901	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation altering degron motif	0.6758
p.D386N	DO48016	STAD	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.25
p.G392V	DO48020	STAD	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0833
p.Q268R	DO229264	THCA	ICGC	ERDLLSDLQ	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.2222
p.A388V	DO43306	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.1944
p.S299P	SIDM01314	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.25
p.G382R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation altering degron motif	0.7568
p.S374N	ACH-000970	Colon/Colorectal Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.2222
p.D392N	IGROV-1	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0833
p.D392N	IST-MEL1	skin	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0833
p.D392N	KNS-42	central nervous system	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0833
p.D392N	OC-314	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0833
p.D392N	PANC-03-27	pancreas	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation rewiring degron network	0.0833
p.D382N	OC-314	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation altering degron motif	0.6932
p.D382N	PANC-03-27	pancreas	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation altering degron motif	0.6932
p.D382N	IGROV-1	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation altering degron motif	0.6932
p.D382N	KNS-42	central nervous system	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation altering degron motif	0.6932
p.D382N	IST-MEL1	skin	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	378:383	Mutation altering degron motif	0.6932

Kaplan plot for CDK11B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK11B

UniProt ID: P21127

Entrez ID: 984

Protein name: Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDK11B in