DegronMD

Uniprot ID: P21127

Source protein: Cyclin-dependent kinase 11B

Source gene: CDK11B

Class: DEG_Kelch_Keap1_1

Location: 378:383

E3 ligase: KEAP1

DEGRON score: 0.8997

ASA_SCORE: 94.8333

COIL: 0.882

CONS_SCORE: 0.2874

DSS_SCORE: 0.7712

HELIX: 0.1098

FCONS_SCORE: 0.9919

RIG_SCORE: 0.5954

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A390V	TCGA-AP-A0LM	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.1389
p.D368N	TCGA-CG-5721	STAD	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D368N	TCGA-EY-A1GI	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.E383D	TCGA-D3-A2J6	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.6758
p.R369L	TCGA-DD-AADE	LIHC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.E393D	TCGA-EE-A17Y	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.P386S	TCGA-FS-A1ZK	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.25
p.G384A	TCGA-L5-A43C	ESCA	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.75
p.D393N	DO224726	COCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	DO222860	COCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	DO222829	COCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	DO222856	COCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	DO231108	LAML	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	DO229257	THCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	DO229213	THCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	OC-314	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	IGROV-1	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	IST-MEL1	skin	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	PANC-03-27	pancreas	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D393N	KNS-42	central_nervous_system	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.S376R	DO229045	LICA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.2778
p.P384S	DO37474	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.75
p.E391D	DO47459	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.1111
p.E381D	DO37901	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.6758
p.D386N	DO48016	STAD	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.25
p.G392V	DO48020	STAD	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.A388V	DO43306	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.1944
p.G382R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DRDSGE	DEG_Kelch_Keap1_1	0.7568
p.S374N	ACH-000970	Colon/Colorectal Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	0.2222
p.D392N	IGROV-1	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.D392N	IST-MEL1	skin	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.D392N	KNS-42	central_nervous_system	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.D392N	OC-314	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.D392N	PANC-03-27	pancreas	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.D382N	OC-314	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.6932
p.D382N	PANC-03-27	pancreas	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.6932
p.D382N	IGROV-1	ovary	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.6932
p.D382N	KNS-42	central_nervous_system	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.6932
p.D382N	IST-MEL1	skin	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21127	Cyclin-dependent kinase 11B	DEG_Kelch_Keap1_1	378:383	DRDSGE	KEAP1	0.8997	More...
Q9UQ88	Cyclin-dependent kinase 11A	DEG_Kelch_Keap1_1	366:371	DRDSGE	KEAP1	0.9721	More...
Q9Y5E5	Protocadherin beta-4	DEG_Kelch_Keap1_1	371:376	DRDSGE	KEAP1	0.5628	More...
Q9Y5E8	Protocadherin beta-15	DEG_Kelch_Keap1_1	372:377	DRDSGE	KEAP1	0.6657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRDSGE

Degron related mutations and impact score

Drug responses associated with CDK11B mutations

All proteins holding degron of DRDSGE