DegronMD - Q9UQ88(CDK11A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P381L	TCGA-B5-A3FC	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.0556
p.D363N	TCGA-CG-5721	STAD	TCGA	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.25
p.D363N	TCGA-EY-A1GI	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.25
p.E378D	TCGA-D3-A3C6	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.1389
p.E378K	DO456	BLCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.1389
p.P380Q	DO229019	LICA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.0833
p.G357R	DO231091	LUSC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.0833
p.G357R	DO229257	THCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.0833
p.G357R	DO229208	THCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.0833
p.G357R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.0833
p.S359L	DO222521	MELA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.1389
p.E377D	DO37507	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.1667
p.D362N	DO38192	STAD	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.2222
p.D362N	DO41211	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.2222
p.Q268R	DO229264	THCA	ICGC	ERDLLSDLQ	DEG_APCC_DBOX_1	260:268	Mutation altering degron motif	0.6218
p.G379D	DO43274	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation rewiring degron network	0.1111
p.P371L	DO41871	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation altering degron motif	0.7582
p.G366R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation altering degron motif	0.7568
p.G370R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation altering degron motif	0.7568
p.G367R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	366:371	Mutation altering degron motif	0.7568

Kaplan plot for CDK11A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK11A

UniProt ID: Q9UQ88

Entrez ID: 728642

Protein name: Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDK11A in