DegronMD

Uniprot ID: Q9UQ88

Source protein: Cyclin-dependent kinase 11A

Source gene: CDK11A

Class: DEG_Kelch_Keap1_1

Location: 366:371

E3 ligase: KEAP1

DEGRON score: 0.9721

ASA_SCORE: 95.8

COIL: 0.9127

CONS_SCORE: 0.2659

DSS_SCORE: 0.7699

HELIX: 0.0765

FCONS_SCORE: 1.0186

RIG_SCORE: 0.5954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P381L	TCGA-B5-A3FC	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.0556
p.D363N	TCGA-CG-5721	STAD	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.25
p.D363N	TCGA-EY-A1GI	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.25
p.E378D	TCGA-D3-A3C6	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.1389
p.E378K	DO456	BLCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.1389
p.P380Q	DO229019	LICA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.G357R	DO231091	LUSC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.G357R	DO229257	THCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.G357R	DO229208	THCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.G357R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.S359L	DO222521	MELA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.1389
p.E377D	DO37507	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.1667
p.D362N	DO38192	STAD	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.2222
p.D362N	DO41211	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.2222
p.G379D	DO43274	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.1111
p.P371L	DO41871	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.7582
p.G366R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.7568
p.G370R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.7568
p.G367R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons