DegronMD

Uniprot ID: Q9Y5E8

Source protein: Protocadherin beta-15

Source gene: PCDHB15

Class: DEG_Kelch_Keap1_1

Location: 372:377

E3 ligase: KEAP1

DEGRON score: 0.6657

ASA_SCORE: 69.6167

COIL: 0.7307

CONS_SCORE: 0.737

DSS_SCORE: 0.3551

HELIX: 0.1257

FCONS_SCORE: 1.1234

RIG_SCORE: 0.6965

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G376R	TCGA-98-A53I	LUSC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.7568
p.G376R	DO219182	LUSC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.7568
p.S375Y	TCGA-AX-A2HC	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.712
p.S375Y	DO41572	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.712
p.R373Q	TCGA-AX-A2HD	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.6218
p.R373Q	DO42608	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.6218
p.T363I	TCGA-BR-A4QL	STAD	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.T363I	DO38723	STAD	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.Q386H	TCGA-D3-A2JL	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.Q386H	DO47278	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.G379E	TCGA-EE-A2GR	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.2778
p.G379E	DO37996	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.2778
p.E364K	TCGA-FW-A3R5	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.1111
p.E364K	DO37406	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.1111
p.G376W	DO229035	LICA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.7825
p.M381I	DO220906	MELA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.2222
p.M381I	SIDM00179	Melanoma	GDSC	DRDSGE	DEG_Kelch_Keap1_1	0.2222
p.M381I	ACH-002165	Skin Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	0.2222
p.M381I	MZ2-MEL	skin	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.2222
p.R371K	DO222413	MELA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.3056
p.E377K	SIDM00614	Hepatocellular Carcinoma	GDSC	DRDSGE	DEG_Kelch_Keap1_1	0.7022
p.E377K	SIDM01210	Glioblastoma	GDSC	DRDSGE	DEG_Kelch_Keap1_1	0.7022
p.E377K	ACH-000479	Brain Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	0.7022
p.E377K	ACH-000848	Liver Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	0.7022
p.E377K	ACH-002259	Brain Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	0.7022
p.E377K	KNS-81-FD	central_nervous_system	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.7022
p.E377K	JHH-7	liver	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.7022
p.Q386P	SIDM01658	Unknown	GDSC	DRDSGE	DEG_Kelch_Keap1_1	0.0833
p.Q386P	ACH-000598	Myeloma	CCLE	DRDSGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21127	Cyclin-dependent kinase 11B	DEG_Kelch_Keap1_1	378:383	DRDSGE	KEAP1	0.8997	More...
Q9UQ88	Cyclin-dependent kinase 11A	DEG_Kelch_Keap1_1	366:371	DRDSGE	KEAP1	0.9721	More...
Q9Y5E5	Protocadherin beta-4	DEG_Kelch_Keap1_1	371:376	DRDSGE	KEAP1	0.5628	More...
Q9Y5E8	Protocadherin beta-15	DEG_Kelch_Keap1_1	372:377	DRDSGE	KEAP1	0.6657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRDSGE

Degron related mutations and impact score

Drug responses associated with PCDHB15 mutations

All proteins holding degron of DRDSGE