DegronMD

Uniprot ID: Q9Y5E5

Source protein: Protocadherin beta-4

Source gene: PCDHB4

Class: DEG_Kelch_Keap1_1

Location: 371:376

E3 ligase: KEAP1

DEGRON score: 0.5628

ASA_SCORE: 70.6833

COIL: 0.7567

CONS_SCORE: 0.6202

DSS_SCORE: 0.2768

HELIX: 0.1155

FCONS_SCORE: 1.1677

RIG_SCORE: 0.714

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D371H	TCGA-XF-AAN4	BLCA	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.7688
p.D371H	DO51943	BLCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.7688
p.S374Y	TCGA-44-7672	LUAD	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.712
p.S374Y	DO23576	LUAD	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.712
p.E376Q	SIDM00473	Oral Cavity Carcinoma	GDSC	DRDSGE	DEG_Kelch_Keap1_1	0.6744
p.E376Q	ACH-000619	Head and Neck Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	0.6744
p.E376Q	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.6744
p.R372K	TCGA-EE-A2A1	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.6126
p.R372K	DO38045	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.6126
p.D371N	TCGA-61-2612	OV	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.5821
p.D371N	DO28161	OV	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.5821
p.R370Q	SIDM01096	Colorectal Carcinoma	GDSC	DRDSGE	DEG_Kelch_Keap1_1	0.3056
p.R370Q	SIDM01175	Other Sarcomas	GDSC	DRDSGE	DEG_Kelch_Keap1_1	0.3056
p.R370Q	ACH-000400	Colon/Colorectal Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	0.3056
p.R370Q	ACH-002309	Sarcoma	CCLE	DRDSGE	DEG_Kelch_Keap1_1	0.3056
p.R370Q	SW684	soft_tissue	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	0.3056
p.R368Q	TCGA-DK-A6AW	BLCA	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.25
p.R368Q	TCGA-EO-A22X	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.25
p.R368Q	TCGA-F5-6814	READ	TCGA	DRDSGE	DEG_Kelch_Keap1_1	0.25
p.R368Q	DO48566	BLCA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.25
p.R368Q	DO36556	READ	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.25
p.R368Q	DO43907	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.25
p.F367S	DO45094	LIRI	ICGC	DRDSGE	DEG_Kelch_Keap1_1	0.2222
p.S383T	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	DRDSGE	DEG_Kelch_Keap1_1	0.1389
p.S383T	ACH-000951	Lung Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	0.1389

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Drug responses associated with PCDHB4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of DRDSGE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ88	Cyclin-dependent kinase 11A	DEG_Kelch_Keap1_1	366:371	DRDSGE	KEAP1	0.9721	More...
P21127	Cyclin-dependent kinase 11B	DEG_Kelch_Keap1_1	378:383	DRDSGE	KEAP1	0.8997	More...
Q9Y5E8	Protocadherin beta-15	DEG_Kelch_Keap1_1	372:377	DRDSGE	KEAP1	0.6657	More...
Q9Y5E5	Protocadherin beta-4	DEG_Kelch_Keap1_1	371:376	DRDSGE	KEAP1	0.5628	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRDSGE

Degron related mutations and impact score

Drug responses associated with PCDHB4 mutations

All proteins holding degron of DRDSGE