DegronMD - Q9Y5E8(PCDHB15)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T145S	TCGA-05-4398	LUAD	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation altering degron motif	0.6005
p.T145S	DO25847	LUAD	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation altering degron motif	0.6005
p.F152L	TCGA-16-0861	GBM	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1944
p.F152L	DO12064	GBM	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1944
p.G376R	TCGA-98-A53I	LUSC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.7568
p.G376R	DO219182	LUSC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.7568
p.S375Y	TCGA-AX-A2HC	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.712
p.S375Y	DO41572	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.712
p.R373Q	TCGA-AX-A2HD	UCEC	TCGA	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.6218
p.R373Q	DO42608	UCEC	ICGC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.6218
p.T363I	TCGA-BR-A4QL	STAD	TCGA	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.0833
p.T363I	DO38723	STAD	ICGC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.0833
p.E135K	TCGA-CN-A6V1	HNSC	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.E135K	TCGA-E7-A85H	BLCA	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.E135K	DO219018	BLCA	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.E135K	DO52048	HNSC	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.Q386H	TCGA-D3-A2JL	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.0833
p.Q386H	DO47278	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.0833
p.K141E	TCGA-DX-AB2Q	SARC	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2778
p.K141E	DO220087	SARC	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2778
p.P134S	TCGA-EB-A44P	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0833
p.P134S	TCGA-EE-A2MT	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0833
p.P134S	DO47525	SKCM	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0833
p.P134S	DO38051	SKCM	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0833
p.G379E	TCGA-EE-A2GR	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.2778
p.G379E	DO37996	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.2778
p.I142T	TCGA-EX-A8YF	CESC	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.3056
p.I142T	DO49970	CESC	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.3056
p.K155R	TCGA-EY-A1G8	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation substituting flanking lysine	0.2222
p.K155R	DO43578	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation substituting flanking lysine	0.2222
p.E364K	TCGA-FW-A3R5	SKCM	TCGA	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.1111
p.E364K	DO37406	SKCM	ICGC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.1111
p.P143T	TCGA-NC-A5HE	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation altering degron motif	0.7031
p.P143T	DO45453	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation altering degron motif	0.7031
p.P143Q	TCGA-NC-A5HE	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	143:147	Mutation altering degron motif	0.7035
p.P143Q	DO45453	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation altering degron motif	0.7035
p.P153S	DO222892	BTCA	ICGC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1667
p.P153S	SIDM00078	Oral Cavity Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1667
p.P153S	SIDM00080	Melanoma	GDSC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1667
p.G376W	DO229035	LICA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.7825
p.M381I	DO220906	MELA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.2222
p.M381I	SIDM00179	Melanoma	GDSC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.2222
p.M381I	ACH-002165	Skin Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.2222
p.M381I	MZ2-MEL	skin	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.2222
p.R371K	DO222413	MELA	ICGC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.3056
p.E377K	SIDM00614	Hepatocellular Carcinoma	GDSC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.7022
p.E377K	SIDM01210	Glioblastoma	GDSC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.7022
p.E377K	ACH-000479	Brain Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.7022
p.E377K	ACH-000848	Liver Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.7022
p.E377K	ACH-002259	Brain Cancer	CCLE	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.7022
p.E377K	KNS-81-FD	central nervous system	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.7022
p.E377K	JHH-7	liver	COSMIC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation altering degron motif	0.7022
p.M138I	SIDM00007	Other Solid Cancers	GDSC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1944
p.M138I	ACH-001550	Skin Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1944
p.M138I	MCC13	skin	COSMIC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1944
p.G149E	SIDM00007	Other Solid Cancers	GDSC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2778
p.G149E	ACH-001550	Skin Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2778
p.G149E	MCC13	skin	COSMIC	PETSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2778
p.Q386P	SIDM01658	Unknown	GDSC	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.0833
p.Q386P	ACH-000598	Myeloma	CCLE	DRDSGE	DEG_Kelch_Keap1_1	372:377	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHB15

UniProt ID: Q9Y5E8

Entrez ID: 56121

Protein name: Protocadherin beta-15 (PCDH-beta-15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHB15 in