DegronMD

Uniprot ID: Q9Y5E8

Source protein: Protocadherin beta-15

Source gene: PCDHB15

Class: DEG_SPOP_SBC_1

Location: 143:147

E3 ligase: SPOP

DEGRON score: 0.7195

ASA_SCORE: 48.02

COIL: 0.6274

CONS_SCORE: 0.6573

DSS_SCORE: 0.3966

HELIX: 0.0328

FCONS_SCORE: 1.0525

RIG_SCORE: 0.7284

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T145S	TCGA-05-4398	LUAD	TCGA	PETSS	DEG_SPOP_SBC_1	0.6005
p.T145S	DO25847	LUAD	ICGC	PETSS	DEG_SPOP_SBC_1	0.6005
p.F152L	TCGA-16-0861	GBM	TCGA	PETSS	DEG_SPOP_SBC_1	0.1944
p.F152L	DO12064	GBM	ICGC	PETSS	DEG_SPOP_SBC_1	0.1944
p.E135K	TCGA-CN-A6V1	HNSC	TCGA	PETSS	DEG_SPOP_SBC_1	0.1111
p.E135K	TCGA-E7-A85H	BLCA	TCGA	PETSS	DEG_SPOP_SBC_1	0.1111
p.E135K	DO219018	BLCA	ICGC	PETSS	DEG_SPOP_SBC_1	0.1111
p.E135K	DO52048	HNSC	ICGC	PETSS	DEG_SPOP_SBC_1	0.1111
p.K141E	TCGA-DX-AB2Q	SARC	TCGA	PETSS	DEG_SPOP_SBC_1	0.2778
p.K141E	DO220087	SARC	ICGC	PETSS	DEG_SPOP_SBC_1	0.2778
p.P134S	TCGA-EB-A44P	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	0.0833
p.P134S	TCGA-EE-A2MT	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	0.0833
p.P134S	DO47525	SKCM	ICGC	PETSS	DEG_SPOP_SBC_1	0.0833
p.P134S	DO38051	SKCM	ICGC	PETSS	DEG_SPOP_SBC_1	0.0833
p.I142T	TCGA-EX-A8YF	CESC	TCGA	PETSS	DEG_SPOP_SBC_1	0.3056
p.I142T	DO49970	CESC	ICGC	PETSS	DEG_SPOP_SBC_1	0.3056
p.K155R	TCGA-EY-A1G8	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	0.2222
p.K155R	DO43578	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	0.2222
p.P143T	TCGA-NC-A5HE	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	0.7031
p.P143T	DO45453	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	0.7031
p.P143Q	TCGA-NC-A5HE	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	0.7035
p.P143Q	DO45453	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	0.7035
p.P153S	DO222892	BTCA	ICGC	PETSS	DEG_SPOP_SBC_1	0.1667
p.P153S	SIDM00078	Oral Cavity Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1667
p.P153S	SIDM00080	Melanoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1667
p.M138I	SIDM00007	Other Solid Cancers	GDSC	PETSS	DEG_SPOP_SBC_1	0.1944
p.M138I	ACH-001550	Skin Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.1944
p.M138I	MCC13	skin	COSMIC	PETSS	DEG_SPOP_SBC_1	0.1944
p.G149E	SIDM00007	Other Solid Cancers	GDSC	PETSS	DEG_SPOP_SBC_1	0.2778
p.G149E	ACH-001550	Skin Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.2778
p.G149E	MCC13	skin	COSMIC	PETSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2431:2435	PETSS	SPOP	0.9627	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	140:144	PETSS	SPOP	0.963	More...
P49116	Nuclear receptor subfamily 2 group C member 2	DEG_SPOP_SBC_1	69:73	PETSS	SPOP	0.9587	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	444:448	PETSS	SPOP	0.5922	More...
Q5JXC2	Migration and invasion-inhibitory protein	DEG_SPOP_SBC_1	55:59	PETSS	SPOP	0.7541	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_SPOP_SBC_1	77:81	PETSS	SPOP	0.8068	More...
Q8IYB4	PEX5-related protein	DEG_SPOP_SBC_1	161:165	PETSS	SPOP	0.8276	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	1634:1638	PETSS	SPOP	0.7934	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2775:2779	PETSS	SPOP	0.9491	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	38:42	PETSS	SPOP	0.9647	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	572:576	PETSS	SPOP	0.5145	More...
Q9Y5E8	Protocadherin beta-15	DEG_SPOP_SBC_1	143:147	PETSS	SPOP	0.7195	More...
A2AJT9	BCLAF1 and THRAP3 family member 3	DEG_SPOP_SBC_1	269:273	PETSS	SPOP	0.866	More...
P78312	Protein FAM193A	DEG_SPOP_SBC_1	979:983	PETSS	SPOP	0.9825	More...
P0C874	Spermatogenesis-associated protein 31D3	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.6572	More...
Q5T1A1	DC-STAMP domain-containing protein 2	DEG_SPOP_SBC_1	739:743	PETSS	SPOP	0.9843	More...
Q6ZQQ2	Spermatogenesis-associated protein 31D1	DEG_SPOP_SBC_1	789:793	PETSS	SPOP	0.8868	More...
Q6ZUB0	Spermatogenesis-associated protein 31D4	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.8838	More...
Q9ULG3	Uncharacterized protein CFAP92	DEG_SPOP_SBC_1	276:280	PETSS	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETSS

Degron related mutations and impact score

Drug responses associated with PCDHB15 mutations

All proteins holding degron of PETSS