DegronMD - Q5T1A1(DCST2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A744T	TCGA-A6-2686	COAD	TCGA	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.3056
p.A744T	TCGA-XK-AAIW	PRAD	TCGA	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.3056
p.A744T	DO7828	COAD	ICGC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.3056
p.A744T	DO51407	PRAD	ICGC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.3056
p.A748D	TCGA-FI-A2F4	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.1944
p.A748D	DO43434	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.1944
p.S742C	TCGA-UY-A9PB	BLCA	TCGA	PETSS	DEG_SPOP_SBC_1	739:743	Mutation altering degron motif	0.7541
p.S742C	DO219041	BLCA	ICGC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation altering degron motif	0.7541
p.H736Q	DO228976	LICA	ICGC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.25
p.A748T	DO232224	PBCA	ICGC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.1944
p.H736Y	DO230590	PRAD	ICGC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.25
p.P739A	SIDM00924	Other Solid Cancers	GDSC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation altering degron motif	0.6392
p.P739A	ACH-000867	Lung Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	739:743	Mutation altering degron motif	0.6392
p.P739A	ChaGo-K-1	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation altering degron motif	0.6392
p.A752V	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.0833
p.A752V	ACH-000451	Lung Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.0833
p.A752V	NCI-H2085	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.0833

Kaplan plot for DCST2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCST2

UniProt ID: Q5T1A1

Entrez ID: 127579

Protein name: DC-STAMP domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCST2 in