DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PETSS
Uniprot ID:
Q5T1A1
Source protein:
DC-STAMP domain-containing protein 2
Source gene:
DCST2
Class:
DEG_SPOP_SBC_1
Location:
739:743
E3 ligase:
SPOP
DEGRON score:
0.9843
ASA_SCORE:
81.8
COIL:
0.8874
CONS_SCORE:
0.1082
DSS_SCORE:
0.8826
HELIX:
0.0676
FCONS_SCORE:
1.117
RIG_SCORE:
0.5139
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A744T
TCGA-A6-2686
COAD
TCGA
PETSS
DEG_SPOP_SBC_1
0.3056
p.A744T
TCGA-XK-AAIW
PRAD
TCGA
PETSS
DEG_SPOP_SBC_1
0.3056
p.A744T
DO7828
COAD
ICGC
PETSS
DEG_SPOP_SBC_1
0.3056
p.A744T
DO51407
PRAD
ICGC
PETSS
DEG_SPOP_SBC_1
0.3056
p.A748D
TCGA-FI-A2F4
UCEC
TCGA
PETSS
DEG_SPOP_SBC_1
0.1944
p.A748D
DO43434
UCEC
ICGC
PETSS
DEG_SPOP_SBC_1
0.1944
p.S742C
TCGA-UY-A9PB
BLCA
TCGA
PETSS
DEG_SPOP_SBC_1
0.7541
p.S742C
DO219041
BLCA
ICGC
PETSS
DEG_SPOP_SBC_1
0.7541
p.H736Q
DO228976
LICA
ICGC
PETSS
DEG_SPOP_SBC_1
0.25
p.A748T
DO232224
PBCA
ICGC
PETSS
DEG_SPOP_SBC_1
0.1944
p.H736Y
DO230590
PRAD
ICGC
PETSS
DEG_SPOP_SBC_1
0.25
p.P739A
SIDM00924
Other Solid Cancers
GDSC
PETSS
DEG_SPOP_SBC_1
0.6392
p.P739A
ACH-000867
Lung Cancer
CCLE
PETSS
DEG_SPOP_SBC_1
0.6392
p.P739A
ChaGo-K-1
lung
COSMIC
PETSS
DEG_SPOP_SBC_1
0.6392
p.A752V
SIDM00709
Non-Small Cell Lung Carcinoma
GDSC
PETSS
DEG_SPOP_SBC_1
0.0833
p.A752V
ACH-000451
Lung Cancer
CCLE
PETSS
DEG_SPOP_SBC_1
0.0833
p.A752V
NCI-H2085
lung
COSMIC
PETSS
DEG_SPOP_SBC_1
0.0833
Drug responses associated with DCST2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PETSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15018
PDZ domain-containing protein 2
DEG_SPOP_SBC_1
2431:2435
PETSS
SPOP
0.9627
More...
P16150
Leukosialin
DEG_SPOP_SBC_1
140:144
PETSS
SPOP
0.963
More...
P49116
Nuclear receptor subfamily 2 group C member 2
DEG_SPOP_SBC_1
69:73
PETSS
SPOP
0.9587
More...
Q2KHR2
DNA-binding protein RFX7
DEG_SPOP_SBC_1
444:448
PETSS
SPOP
0.5922
More...
Q5JXC2
Migration and invasion-inhibitory protein
DEG_SPOP_SBC_1
55:59
PETSS
SPOP
0.7541
More...
Q5TD94
Radial spoke head protein 4 homolog A
DEG_SPOP_SBC_1
77:81
PETSS
SPOP
0.8068
More...
Q8IYB4
PEX5-related protein
DEG_SPOP_SBC_1
161:165
PETSS
SPOP
0.8276
More...
Q8IZF0
Sodium leak channel NALCN
DEG_SPOP_SBC_1
1634:1638
PETSS
SPOP
0.7934
More...
Q96JG9
Zinc finger protein 469
DEG_SPOP_SBC_1
2775:2779
PETSS
SPOP
0.9491
More...
Q99504
Eyes absent homolog 3
DEG_SPOP_SBC_1
38:42
PETSS
SPOP
0.9647
More...
Q9NR48
Histone-lysine N-methyltransferase ASH1L
DEG_SPOP_SBC_1
572:576
PETSS
SPOP
0.5145
More...
Q9Y5E8
Protocadherin beta-15
DEG_SPOP_SBC_1
143:147
PETSS
SPOP
0.7195
More...
A2AJT9
BCLAF1 and THRAP3 family member 3
DEG_SPOP_SBC_1
269:273
PETSS
SPOP
0.866
More...
P78312
Protein FAM193A
DEG_SPOP_SBC_1
979:983
PETSS
SPOP
0.9825
More...
P0C874
Spermatogenesis-associated protein 31D3
DEG_SPOP_SBC_1
786:790
PETSS
SPOP
0.6572
More...
Q5T1A1
DC-STAMP domain-containing protein 2
DEG_SPOP_SBC_1
739:743
PETSS
SPOP
0.9843
More...
Q6ZQQ2
Spermatogenesis-associated protein 31D1
DEG_SPOP_SBC_1
789:793
PETSS
SPOP
0.8868
More...
Q6ZUB0
Spermatogenesis-associated protein 31D4
DEG_SPOP_SBC_1
786:790
PETSS
SPOP
0.8838
More...
Q9ULG3
Uncharacterized protein CFAP92
DEG_SPOP_SBC_1
276:280
PETSS
SPOP
0.9829
More...