DegronMD - Q6ZQQ2(SPATA31D1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S162L	TCGA-05-4405	LUAD	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.S162L	DO24656	LUAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.D796Y	TCGA-06-0190	GBM	TCGA	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.25
p.D796Y	TCGA-BQ-5893	KIRP	TCGA	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.25
p.D796Y	DO10975	GBM	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.25
p.D796Y	DO20895	KIRP	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.25
p.R189L	TCGA-09-2044	OV	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.R189L	TCGA-77-A5G3	LUSC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.R189L	TCGA-FS-A1ZG	SKCM	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.R189L	DO45456	LUSC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.R189L	DO28923	OV	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.R189L	DO37523	SKCM	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.V1542F	TCGA-55-8506	LUAD	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.1944
p.V1542F	DO45390	LUAD	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.1944
p.P188T	TCGA-55-8616	LUAD	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0833
p.P188T	TCGA-FI-A2D0	UCEC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0833
p.P188T	DO23566	LUAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0833
p.P188T	DO43891	UCEC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0833
p.E790D	TCGA-56-7823	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	789:793	Mutation altering degron motif	0.5647
p.E790D	DO223721	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation altering degron motif	0.5647
p.A165E	TCGA-95-7562	LUAD	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1389
p.A165E	DO51196	LUAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1389
p.S801C	TCGA-A2-A0CL	BRCA	TCGA	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.1111
p.S801C	DO2155	BRCA	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.1111
p.P1543R	TCGA-A6-6651	COAD	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.2222
p.P1543R	TCGA-CN-5360	HNSC	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.2222
p.P1543R	DO8328	COAD	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.2222
p.P1543R	DO14662	HNSC	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.2222
p.E167G	TCGA-A8-A09Z	BRCA	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1944
p.E167G	DO5521	BRCA	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1944
p.T171I	TCGA-AA-A00N	COAD	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.3056
p.T171I	DO9876	COAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.3056
p.T1558N	TCGA-AN-A046	BRCA	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation blocking phosphorylation signal	0.6389
p.T1558N	DO1285	BRCA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation blocking phosphorylation signal	0.6389
p.P789L	TCGA-AP-A0LM	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	789:793	Mutation altering degron motif	0.7582
p.P789L	TCGA-HT-8564	LGG	TCGA	PETSS	DEG_SPOP_SBC_1	789:793	Mutation altering degron motif	0.7582
p.P789L	DO44623	LGG	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation altering degron motif	0.7582
p.P789L	DO43306	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation altering degron motif	0.7582
p.R93S	TCGA-B6-A0RH	BRCA	TCGA	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.7427
p.R93S	DO2162	BRCA	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.7427
p.E167Q	TCGA-CN-4723	HNSC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1944
p.E167Q	DO14830	HNSC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1944
p.E182V	TCGA-CQ-7068	HNSC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.25
p.E182V	DO15551	HNSC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.25
p.V780A	TCGA-CV-6941	HNSC	TCGA	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.0833
p.V780A	DO15919	HNSC	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.0833
p.V780A	HCC70	breast	COSMIC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.0833
p.F1551V	TCGA-D7-6528	STAD	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation altering degron motif	0.7068
p.F1551V	DO234445	ESAD	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation altering degron motif	0.7068
p.F1551V	DO38547	STAD	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation altering degron motif	0.7068
p.R189Q	TCGA-DF-A2KN	UCEC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.R189Q	DO220886	MELA	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.R189Q	DO223282	UCEC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0556
p.S84R	TCGA-E6-A1LX	UCEC	TCGA	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1111
p.S84R	DO41020	UCEC	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1111
p.P1543S	TCGA-EE-A2MT	SKCM	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.2222
p.P1543S	DO38051	SKCM	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.2222
p.D796N	TCGA-EE-A3JA	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.25
p.D796N	DO47625	SKCM	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.25
p.D183H	TCGA-IG-A97I	ESCA	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.2222
p.A1546V	TCGA-L5-A4OG	ESCA	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.3056
p.P1543Q	TCGA-LN-A9FP	ESCA	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.2222
p.L186Q	TCGA-NC-A5HT	LUSC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1389
p.L186Q	DO234461	ESAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1389
p.L186Q	DO219205	LUSC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1389
p.K795N	TCGA-OR-A5KB	ACC	TCGA	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.2778
p.A173D	TCGA-VQ-A91X	STAD	TCGA	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation altering degron motif	0.6682
p.A173D	DO51790	STAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation altering degron motif	0.6682
p.A165V	DO222884	COCA	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1389
p.A165V	SIDM01694	B-Lymphoblastic Leukemia	GDSC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1389
p.A165V	ACH-000728	Leukemia	CCLE	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1389
p.T1558P	DO233267	GACA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation blocking phosphorylation signal	0.6389
p.S1548N	DO233652	GACA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation altering degron motif	0.5958
p.L96P	DO233736	GACA	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.7582
p.T1544P	DO233926	GACA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.25
p.A165S	DO14420	HNSC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.1389
p.S84I	DO228655	LICA	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1111
p.S84I	DO229026	LICA	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1111
p.S1548I	DO228948	LICA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation altering degron motif	0.623
p.S1548I	DO229038	LICA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation altering degron motif	0.623
p.G1559V	DO229009	LICA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.1667
p.S177P	DO23378	LINC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation altering degron motif	0.5641
p.P1549L	DO231047	LUSC	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation altering degron motif	0.6471
p.G788V	DO231191	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.3056
p.S97F	DO222420	MELA	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6871
p.D796G	DO50701	ORCA	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.25
p.P781R	DO27953	ORCA	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.1111
p.P1555S	DO224719	PACA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.2778
p.V780F	DO229584	PRAD	ICGC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation rewiring degron network	0.0833
p.P188S	SIDM00705	Non-Cancerous	GDSC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0833
p.P188S	SIDM00696	Non-Cancerous	GDSC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0833
p.P188S	SIDM00772	Breast Carcinoma	GDSC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0833
p.P188S	SIDM01088	Endometrial Carcinoma	GDSC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0833
p.P188S	ACH-000965	Endometrial/Uterine Cancer	CCLE	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0833
p.P188S	ACH-002369	Non-Cancerous	CCLE	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.0833
p.P1549H	SIDM00596	Endometrial Carcinoma	GDSC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation altering degron motif	0.6583
p.P1549H	ACH-001517	Endometrial/Uterine Cancer	CCLE	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation altering degron motif	0.6583
p.P1549H	HEC-1	endometrium	COSMIC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation altering degron motif	0.6583
p.K782N	SIDM00841	Colorectal Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation substituting flanking lysine	0.25
p.K782N	ACH-000651	Colon/Colorectal Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	789:793	Mutation substituting flanking lysine	0.25
p.K782N	SW620	large intestine	COSMIC	PETSS	DEG_SPOP_SBC_1	789:793	Mutation substituting flanking lysine	0.25
p.A173T	SIDM00847	Rhabdomyosarcoma	GDSC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation altering degron motif	0.6028
p.A173T	ACH-000169	Sarcoma	CCLE	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation altering degron motif	0.6028
p.A173T	RD	soft tissue	COSMIC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation altering degron motif	0.6028
p.D183N	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.2222
p.D183N	ACH-000030	Lung Cancer	CCLE	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.2222
p.D183N	ACH-000779	Lung Cancer	CCLE	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.2222
p.D183N	PC-14	lung	COSMIC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation rewiring degron network	0.2222
p.A1546G	SIDM00410	Other Blood Cancers	GDSC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.3056
p.A1546G	ACH-002317	Leukemia	CCLE	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.3056
p.A1546G	YT	haematopoietic and lymphoid tissue	COSMIC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.3056
p.G103R	SIDM00837	Colorectal Carcinoma	GDSC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.25
p.G103R	ACH-000958	Colon/Colorectal Cancer	CCLE	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.25
p.G103R	SW48	large intestine	COSMIC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.25
p.S101I	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.3056
p.S101I	KYSE-150	oesophagus	COSMIC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.3056
p.V1542I	SIDM01578	Bladder Carcinoma	GDSC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.1944
p.V1542I	ACH-000862	Bladder Cancer	CCLE	KSPVFSD	LIG_APCC_ABBAyCdc20_2	1547:1553	Mutation rewiring degron network	0.1944
p.F85Y	ACH-000586	Lung Cancer	CCLE	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1389
p.F85Y	NCI-H1876	lung	COSMIC	ERKLLSLLK	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1389
p.T175N	ACH-001652	Endometrial/Uterine Cancer	CCLE	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation altering degron motif	0.7055
p.T175A	ESS-1	endometrium	COSMIC	LASTPSAT	DEG_SCF_FBW7_1	172:179	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA31D1

UniProt ID: Q6ZQQ2

Entrez ID: 389763

Protein name: Spermatogenesis-associated protein 31D1 (Protein FAM75D1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA31D1 in