DegronMD

Uniprot ID: Q6ZQQ2

Source protein: Spermatogenesis-associated protein 31D1

Source gene: SPATA31D1

Class: LIG_APCC_ABBAyCdc20_2

Location: 1547:1553

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9842

ASA_SCORE: 69.1286

COIL: 0.6884

CONS_SCORE: 0.2858

DSS_SCORE: 0.3327

HELIX: 0.0714

FCONS_SCORE: 1.0014

RIG_SCORE: 0.745

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1542F	TCGA-55-8506	LUAD	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.V1542F	DO45390	LUAD	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P1543R	TCGA-A6-6651	COAD	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P1543R	TCGA-CN-5360	HNSC	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P1543R	DO8328	COAD	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P1543R	DO14662	HNSC	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T1558N	TCGA-AN-A046	BRCA	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.6389
p.T1558N	DO1285	BRCA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.6389
p.F1551V	TCGA-D7-6528	STAD	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.7068
p.F1551V	DO234445	ESAD	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.7068
p.F1551V	DO38547	STAD	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.7068
p.P1543S	TCGA-EE-A2MT	SKCM	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P1543S	DO38051	SKCM	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A1546V	TCGA-L5-A4OG	ESCA	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P1543Q	TCGA-LN-A9FP	ESCA	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T1558P	DO233267	GACA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.6389
p.S1548N	DO233652	GACA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.5958
p.T1544P	DO233926	GACA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.S1548I	DO228948	LICA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.623
p.S1548I	DO229038	LICA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.623
p.G1559V	DO229009	LICA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P1549L	DO231047	LUSC	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.6471
p.P1555S	DO224719	PACA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P1549H	SIDM00596	Endometrial Carcinoma	GDSC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.6583
p.P1549H	ACH-001517	Endometrial/Uterine Cancer	CCLE	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.6583
p.P1549H	HEC-1	endometrium	COSMIC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.6583
p.A1546G	SIDM00410	Other Blood Cancers	GDSC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A1546G	ACH-002317	Leukemia	CCLE	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A1546G	YT	haematopoietic_and_lymphoid_tissue	COSMIC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.V1542I	SIDM01578	Bladder Carcinoma	GDSC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.V1542I	ACH-000862	Bladder Cancer	CCLE	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00566	U3 small nucleolar ribonucleoprotein protein MPP10	LIG_APCC_ABBAyCdc20_2	162:168	KSPVFSD	APC,CDC20,FZR1	0.7582	More...
Q6ZQQ2	Spermatogenesis-associated protein 31D1	LIG_APCC_ABBAyCdc20_2	1547:1553	KSPVFSD	APC,CDC20,FZR1	0.9842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KSPVFSD

Degron related mutations and impact score

Drug responses associated with SPATA31D1 mutations

All proteins holding degron of KSPVFSD