DegronMD

Uniprot ID: O00566

Source protein: U3 small nucleolar ribonucleoprotein protein MPP10

Source gene: MPHOSPH10

Class: LIG_APCC_ABBAyCdc20_2

Location: 162:168

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7582

ASA_SCORE: 95.9857

COIL: 0.8943

CONS_SCORE: 0.3508

DSS_SCORE: 0.5985

HELIX: 0.0803

FCONS_SCORE: 0.9174

RIG_SCORE: 0.6574

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D174N	TCGA-50-5066	LUAD	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D174N	DO25040	LUAD	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S156N	TCGA-BT-A3PH	BLCA	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S156N	DO856	BLCA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D168N	TCGA-CR-5248	HNSC	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D168N	DO14694	HNSC	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.6932
p.E169K	TCGA-NC-A5HD	LUSC	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E169K	DO219184	LUSC	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D174H	TCGA-VS-AA62	CESC	TCGA	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D174H	DO219745	CESC	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.L160M	DO222602	COCA	ICGC	KSPVFSD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00566	U3 small nucleolar ribonucleoprotein protein MPP10	LIG_APCC_ABBAyCdc20_2	162:168	KSPVFSD	APC,CDC20,FZR1	0.7582	More...
Q6ZQQ2	Spermatogenesis-associated protein 31D1	LIG_APCC_ABBAyCdc20_2	1547:1553	KSPVFSD	APC,CDC20,FZR1	0.9842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons