DegronMD

Uniprot ID: Q6ZQQ2

Source protein: Spermatogenesis-associated protein 31D1

Source gene: SPATA31D1

Class: DEG_SCF_FBW7_1

Location: 172:179

E3 ligase: FBXW7

DEGRON score: 0.992

ASA_SCORE: 77.325

COIL: 0.9276

CONS_SCORE: 0.4267

DSS_SCORE: 0.5749

HELIX: 0.0449

FCONS_SCORE: 0.8911

RIG_SCORE: 0.5951

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S162L	TCGA-05-4405	LUAD	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.S162L	DO24656	LUAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.R189L	TCGA-09-2044	OV	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.R189L	TCGA-77-A5G3	LUSC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.R189L	TCGA-FS-A1ZG	SKCM	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.R189L	DO45456	LUSC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.R189L	DO28923	OV	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.R189L	DO37523	SKCM	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.P188T	TCGA-55-8616	LUAD	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.0833
p.P188T	TCGA-FI-A2D0	UCEC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.0833
p.P188T	DO23566	LUAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.0833
p.P188T	DO43891	UCEC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.0833
p.A165E	TCGA-95-7562	LUAD	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.1389
p.A165E	DO51196	LUAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.1389
p.E167G	TCGA-A8-A09Z	BRCA	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.1944
p.E167G	DO5521	BRCA	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.1944
p.T171I	TCGA-AA-A00N	COAD	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.3056
p.T171I	DO9876	COAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.3056
p.E167Q	TCGA-CN-4723	HNSC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.1944
p.E167Q	DO14830	HNSC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.1944
p.E182V	TCGA-CQ-7068	HNSC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.25
p.E182V	DO15551	HNSC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.25
p.R189Q	TCGA-DF-A2KN	UCEC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.R189Q	DO220886	MELA	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.R189Q	DO223282	UCEC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.0556
p.D183H	TCGA-IG-A97I	ESCA	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.2222
p.L186Q	TCGA-NC-A5HT	LUSC	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.1389
p.L186Q	DO234461	ESAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.1389
p.L186Q	DO219205	LUSC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.1389
p.A173D	TCGA-VQ-A91X	STAD	TCGA	LASTPSAT	DEG_SCF_FBW7_1	0.6682
p.A173D	DO51790	STAD	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.6682
p.A165V	DO222884	COCA	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.1389
p.A165V	SIDM01694	B-Lymphoblastic Leukemia	GDSC	LASTPSAT	DEG_SCF_FBW7_1	0.1389
p.A165V	ACH-000728	Leukemia	CCLE	LASTPSAT	DEG_SCF_FBW7_1	0.1389
p.A165S	DO14420	HNSC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.1389
p.S177P	DO23378	LINC	ICGC	LASTPSAT	DEG_SCF_FBW7_1	0.5641
p.P188S	SIDM00705	Non-Cancerous	GDSC	LASTPSAT	DEG_SCF_FBW7_1	0.0833
p.P188S	SIDM00696	Non-Cancerous	GDSC	LASTPSAT	DEG_SCF_FBW7_1	0.0833
p.P188S	SIDM00772	Breast Carcinoma	GDSC	LASTPSAT	DEG_SCF_FBW7_1	0.0833
p.P188S	SIDM01088	Endometrial Carcinoma	GDSC	LASTPSAT	DEG_SCF_FBW7_1	0.0833
p.P188S	ACH-000965	Endometrial/Uterine Cancer	CCLE	LASTPSAT	DEG_SCF_FBW7_1	0.0833
p.P188S	ACH-002369	Non-Cancerous	CCLE	LASTPSAT	DEG_SCF_FBW7_1	0.0833
p.A173T	SIDM00847	Rhabdomyosarcoma	GDSC	LASTPSAT	DEG_SCF_FBW7_1	0.6028
p.A173T	ACH-000169	Sarcoma	CCLE	LASTPSAT	DEG_SCF_FBW7_1	0.6028
p.A173T	RD	soft_tissue	COSMIC	LASTPSAT	DEG_SCF_FBW7_1	0.6028
p.D183N	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	LASTPSAT	DEG_SCF_FBW7_1	0.2222
p.D183N	ACH-000030	Lung Cancer	CCLE	LASTPSAT	DEG_SCF_FBW7_1	0.2222
p.D183N	ACH-000779	Lung Cancer	CCLE	LASTPSAT	DEG_SCF_FBW7_1	0.2222
p.D183N	PC-14	lung	COSMIC	LASTPSAT	DEG_SCF_FBW7_1	0.2222
p.T175N	ACH-001652	Endometrial/Uterine Cancer	CCLE	LASTPSAT	DEG_SCF_FBW7_1	0.7055
p.T175A	ESS-1	endometrium	COSMIC	LASTPSAT	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C874	Spermatogenesis-associated protein 31D3	DEG_SCF_FBW7_1	169:176	LASTPSAT	FBXW7	0.8379	More...
Q6ZQQ2	Spermatogenesis-associated protein 31D1	DEG_SCF_FBW7_1	172:179	LASTPSAT	FBXW7	0.992	More...
Q6ZUB0	Spermatogenesis-associated protein 31D4	DEG_SCF_FBW7_1	169:176	LASTPSAT	FBXW7	0.8197	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LASTPSAT

Degron related mutations and impact score

Drug responses associated with SPATA31D1 mutations

All proteins holding degron of LASTPSAT