DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LASTPSAT
Uniprot ID:
Q6ZUB0
Source protein:
Spermatogenesis-associated protein 31D4
Source gene:
SPATA31D4
Class:
DEG_SCF_FBW7_1
Location:
169:176
E3 ligase:
FBXW7
DEGRON score:
0.8197
ASA_SCORE:
74.975
COIL:
0.9069
CONS_SCORE:
0.3443
DSS_SCORE:
0.546
HELIX:
0.055
FCONS_SCORE:
1.0176
RIG_SCORE:
0.6114
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SPATA31D4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LASTPSAT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0C874
Spermatogenesis-associated protein 31D3
DEG_SCF_FBW7_1
169:176
LASTPSAT
FBXW7
0.8379
More...
Q6ZQQ2
Spermatogenesis-associated protein 31D1
DEG_SCF_FBW7_1
172:179
LASTPSAT
FBXW7
0.992
More...
Q6ZUB0
Spermatogenesis-associated protein 31D4
DEG_SCF_FBW7_1
169:176
LASTPSAT
FBXW7
0.8197
More...