DegronMD

Uniprot ID: Q6ZQQ2

Source protein: Spermatogenesis-associated protein 31D1

Source gene: SPATA31D1

Class: DEG_APCC_DBOX_1

Location: 92:100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5913

ASA_SCORE: 83.0556

COIL: 0.1269

CONS_SCORE: 0.4524

DSS_SCORE: 0.3668

HELIX: 0.874

FCONS_SCORE: 1.1748

RIG_SCORE: 0.7843

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R93S	TCGA-B6-A0RH	BRCA	TCGA	ERKLLSLLK	DEG_APCC_DBOX_1	0.7427
p.R93S	DO2162	BRCA	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	0.7427
p.S84R	TCGA-E6-A1LX	UCEC	TCGA	ERKLLSLLK	DEG_APCC_DBOX_1	0.1111
p.S84R	DO41020	UCEC	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	0.1111
p.L96P	DO233736	GACA	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	0.7582
p.S84I	DO228655	LICA	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	0.1111
p.S84I	DO229026	LICA	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	0.1111
p.S97F	DO222420	MELA	ICGC	ERKLLSLLK	DEG_APCC_DBOX_1	0.6871
p.G103R	SIDM00837	Colorectal Carcinoma	GDSC	ERKLLSLLK	DEG_APCC_DBOX_1	0.25
p.G103R	ACH-000958	Colon/Colorectal Cancer	CCLE	ERKLLSLLK	DEG_APCC_DBOX_1	0.25
p.G103R	SW48	large_intestine	COSMIC	ERKLLSLLK	DEG_APCC_DBOX_1	0.25
p.S101I	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	ERKLLSLLK	DEG_APCC_DBOX_1	0.3056
p.S101I	KYSE-150	oesophagus	COSMIC	ERKLLSLLK	DEG_APCC_DBOX_1	0.3056
p.F85Y	ACH-000586	Lung Cancer	CCLE	ERKLLSLLK	DEG_APCC_DBOX_1	0.1389
p.F85Y	NCI-H1876	lung	COSMIC	ERKLLSLLK	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZQQ2	Spermatogenesis-associated protein 31D1	DEG_APCC_DBOX_1	92:100	ERKLLSLLK	APC,CDC20,FZR1	0.5913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons