DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
CFAP92
UniProt ID:
Q9ULG3
Entrez ID:
57501
Protein name:
Uncharacterized protein CFAP92 (Putative cilia and flagella associated protein 92)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
CFAP92
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.T307S
SIDM00672
Hepatocellular Carcinoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM00454
Rhabdomyosarcoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM00654
Small Cell Lung Carcinoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM00529
Breast Carcinoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM00650
Small Cell Lung Carcinoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM00052
Esophageal Squamous Cell Carcinoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM00703
Non-Small Cell Lung Carcinoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM00254
Neuroblastoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM00032
Bladder Carcinoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM00863
Burkitt's Lymphoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM01681
Non-Cancerous
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.T307S
SIDM00760
Small Cell Lung Carcinoma
GDSC
VSRTPTIS
DEG_SCF_FBW7_1
302:309
Mutation altering degron motif
0.6005
p.E275K
SIDM00156
Neuroblastoma
GDSC
PETSS
DEG_SPOP_SBC_1
276:280
Mutation rewiring degron network
0.3056
p.S271Y
SIDM00451
T-Lymphoblastic Leukemia
GDSC
PETSS
DEG_SPOP_SBC_1
276:280
Mutation rewiring degron network
0.1944
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for CFAP92 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc