DegronMD

Uniprot ID: Q8IYB4

Source protein: PEX5-related protein

Source gene: PEX5L

Class: DEG_SPOP_SBC_1

Location: 161:165

E3 ligase: SPOP

DEGRON score: 0.8276

ASA_SCORE: 76.5

COIL: 0.73

CONS_SCORE: 0.3209

DSS_SCORE: 0.5792

HELIX: 0.19

FCONS_SCORE: 0.9692

RIG_SCORE: 0.7257

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E162D	TCGA-A5-A0G2	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	0.5647
p.P161L	TCGA-AA-3858	COAD	TCGA	PETSS	DEG_SPOP_SBC_1	0.7582
p.P161L	SIDM00687	Gastric Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.7582
p.P161L	ACH-000793	Gastric Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.7582
p.P161L	KATOIII	stomach	COSMIC	PETSS	DEG_SPOP_SBC_1	0.7582
p.E162Q	TCGA-CN-4723	HNSC	TCGA	PETSS	DEG_SPOP_SBC_1	0.5633
p.E175K	TCGA-CV-7568	HNSC	TCGA	PETSS	DEG_SPOP_SBC_1	0.0556
p.D169Y	TCGA-EE-A2GT	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	0.2222
p.S164L	TCGA-L9-A7SV	LUAD	TCGA	PETSS	DEG_SPOP_SBC_1	0.7667
p.Q172H	DO219255	PRAD	ICGC	PETSS	DEG_SPOP_SBC_1	0.1389
p.E158K	DO220056	SARC	ICGC	PETSS	DEG_SPOP_SBC_1	0.25
p.A160S	DO42673	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	0.3056
p.Q173H	SIDM00773	Non-Cancerous	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.Q173H	SIDM00855	Other Sarcomas	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.Q173H	SIDM00529	Breast Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.Q173H	SIDM00493	Other Solid Cancers	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.Q173H	SIDM00309	Mesothelioma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.Q173H	SIDM00032	Bladder Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.Q173H	SIDM00721	Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.Q173H	SIDM00774	Breast Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.Q173H	SIDM00257	Neuroblastoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.L158F	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.25
p.L158F	H513	pleura	COSMIC	PETSS	DEG_SPOP_SBC_1	0.25
p.T163S	SIDM01257	Hepatocellular Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.6005
p.T163S	SIDM00062	Hepatocellular Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.6005
p.T163S	ACH-000671	Liver Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.6005
p.T163S	ACH-002395	Liver Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.6005
p.T163S	HUH-6-clone5	liver	COSMIC	PETSS	DEG_SPOP_SBC_1	0.6005
p.P161Q	ACH-001538	Bile Duct Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.7035
p.P159L	KATOIII	stomach	COSMIC	PETSS	DEG_SPOP_SBC_1	0.2778
p.L161M	NCI-H1105	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	0.711
p.T168S	NCI-H1993	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	0.25
p.V165L	NCI-H2342	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	0.6765
p.S174L	SW684	soft_tissue	COSMIC	PETSS	DEG_SPOP_SBC_1	0.0833
p.L156F	H513	pleura	COSMIC	PETSS	DEG_SPOP_SBC_1	0.1944
p.S170Y	DU-145	prostate	COSMIC	PETSS	DEG_SPOP_SBC_1	0.1944
p.P165L	HCC-366	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	0.7582
p.E159Q	H513	pleura	COSMIC	PETSS	DEG_SPOP_SBC_1	0.2778
p.S155L	SW684	soft_tissue	COSMIC	PETSS	DEG_SPOP_SBC_1	0.1667
p.S163L	SW684	soft_tissue	COSMIC	PETSS	DEG_SPOP_SBC_1	0.7667
p.T161S	HUH-6-clone5	liver	COSMIC	PETSS	DEG_SPOP_SBC_1	0.7116
p.Q163E	NCI-H441	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	0.6744
p.T160S	NCI-H1993	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2431:2435	PETSS	SPOP	0.9627	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	140:144	PETSS	SPOP	0.963	More...
P49116	Nuclear receptor subfamily 2 group C member 2	DEG_SPOP_SBC_1	69:73	PETSS	SPOP	0.9587	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	444:448	PETSS	SPOP	0.5922	More...
Q5JXC2	Migration and invasion-inhibitory protein	DEG_SPOP_SBC_1	55:59	PETSS	SPOP	0.7541	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_SPOP_SBC_1	77:81	PETSS	SPOP	0.8068	More...
Q8IYB4	PEX5-related protein	DEG_SPOP_SBC_1	161:165	PETSS	SPOP	0.8276	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	1634:1638	PETSS	SPOP	0.7934	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2775:2779	PETSS	SPOP	0.9491	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	38:42	PETSS	SPOP	0.9647	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	572:576	PETSS	SPOP	0.5145	More...
Q9Y5E8	Protocadherin beta-15	DEG_SPOP_SBC_1	143:147	PETSS	SPOP	0.7195	More...
A2AJT9	BCLAF1 and THRAP3 family member 3	DEG_SPOP_SBC_1	269:273	PETSS	SPOP	0.866	More...
P78312	Protein FAM193A	DEG_SPOP_SBC_1	979:983	PETSS	SPOP	0.9825	More...
P0C874	Spermatogenesis-associated protein 31D3	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.6572	More...
Q5T1A1	DC-STAMP domain-containing protein 2	DEG_SPOP_SBC_1	739:743	PETSS	SPOP	0.9843	More...
Q6ZQQ2	Spermatogenesis-associated protein 31D1	DEG_SPOP_SBC_1	789:793	PETSS	SPOP	0.8868	More...
Q6ZUB0	Spermatogenesis-associated protein 31D4	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.8838	More...
Q9ULG3	Uncharacterized protein CFAP92	DEG_SPOP_SBC_1	276:280	PETSS	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETSS

Degron related mutations and impact score

Drug responses associated with PEX5L mutations

All proteins holding degron of PETSS