DegronMD - Q8IYB4(PEX5L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E162D	TCGA-A5-A0G2	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.5647
p.P161L	TCGA-AA-3858	COAD	TCGA	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7582
p.P161L	SIDM00687	Gastric Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7582
p.P161L	ACH-000793	Gastric Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7582
p.P161L	KATOIII	stomach	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7582
p.E162Q	TCGA-CN-4723	HNSC	TCGA	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.5633
p.E175K	TCGA-CV-7568	HNSC	TCGA	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0556
p.D169Y	TCGA-EE-A2GT	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.S164L	TCGA-L9-A7SV	LUAD	TCGA	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7667
p.Q172H	DO219255	PRAD	ICGC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1389
p.E158K	DO220056	SARC	ICGC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.25
p.A160S	DO42673	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056
p.Q173H	SIDM00773	Non-Cancerous	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.Q173H	SIDM00855	Other Sarcomas	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.Q173H	SIDM00529	Breast Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.Q173H	SIDM00493	Other Solid Cancers	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.Q173H	SIDM00309	Mesothelioma	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.Q173H	SIDM00032	Bladder Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.Q173H	SIDM00721	Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.Q173H	SIDM00774	Breast Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.Q173H	SIDM00257	Neuroblastoma	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.L158F	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.25
p.L158F	H513	pleura	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.25
p.T163S	SIDM01257	Hepatocellular Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.6005
p.T163S	SIDM00062	Hepatocellular Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.6005
p.T163S	ACH-000671	Liver Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.6005
p.T163S	ACH-002395	Liver Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.6005
p.T163S	HUH-6-clone5	liver	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.6005
p.P161Q	ACH-001538	Bile Duct Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7035
p.P159L	KATOIII	stomach	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2778
p.L161M	NCI-H1105	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.711
p.T168S	NCI-H1993	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.25
p.V165L	NCI-H2342	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.6765
p.S174L	SW684	soft tissue	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.L156F	H513	pleura	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1944
p.S170Y	DU-145	prostate	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1944
p.P165L	HCC-366	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7582
p.E159Q	H513	pleura	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2778
p.S155L	SW684	soft tissue	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1667
p.S163L	SW684	soft tissue	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7667
p.T161S	HUH-6-clone5	liver	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7116
p.Q163E	NCI-H441	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.6744
p.T160S	NCI-H1993	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PEX5L

UniProt ID: Q8IYB4

Entrez ID: 51555

Protein name: PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Peroxisome biogenesis factor 5-like) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PEX5L in