DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_SPOP_SBC_1

Location: 2431:2435

E3 ligase: SPOP

DEGRON score: 0.9627

ASA_SCORE: 96.96

COIL: 0.9424

CONS_SCORE: 0.3734

DSS_SCORE: 0.7246

HELIX: 0.0314

FCONS_SCORE: 1.014

RIG_SCORE: 0.5691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M2421I	TCGA-58-8393	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	0.0556
p.M2421I	DO45498	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	0.0556
p.E2432Q	TCGA-BH-A0W7	BRCA	TCGA	PETSS	DEG_SPOP_SBC_1	0.5633
p.E2432Q	DO1272	BRCA	ICGC	PETSS	DEG_SPOP_SBC_1	0.5633
p.R2427W	TCGA-CA-6717	COAD	TCGA	PETSS	DEG_SPOP_SBC_1	0.2222
p.R2427W	DO8264	COAD	ICGC	PETSS	DEG_SPOP_SBC_1	0.2222
p.S2440L	TCGA-CA-6717	COAD	TCGA	PETSS	DEG_SPOP_SBC_1	0.6389
p.S2440L	DO8264	COAD	ICGC	PETSS	DEG_SPOP_SBC_1	0.6389
p.P2430T	TCGA-EE-A2GN	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	0.3056
p.P2430T	DO37896	SKCM	ICGC	PETSS	DEG_SPOP_SBC_1	0.3056
p.G2437C	DO233259	GACA	ICGC	PETSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2431:2435	PETSS	SPOP	0.9627	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	140:144	PETSS	SPOP	0.963	More...
P49116	Nuclear receptor subfamily 2 group C member 2	DEG_SPOP_SBC_1	69:73	PETSS	SPOP	0.9587	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	444:448	PETSS	SPOP	0.5922	More...
Q5JXC2	Migration and invasion-inhibitory protein	DEG_SPOP_SBC_1	55:59	PETSS	SPOP	0.7541	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_SPOP_SBC_1	77:81	PETSS	SPOP	0.8068	More...
Q8IYB4	PEX5-related protein	DEG_SPOP_SBC_1	161:165	PETSS	SPOP	0.8276	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	1634:1638	PETSS	SPOP	0.7934	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2775:2779	PETSS	SPOP	0.9491	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	38:42	PETSS	SPOP	0.9647	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	572:576	PETSS	SPOP	0.5145	More...
Q9Y5E8	Protocadherin beta-15	DEG_SPOP_SBC_1	143:147	PETSS	SPOP	0.7195	More...
A2AJT9	BCLAF1 and THRAP3 family member 3	DEG_SPOP_SBC_1	269:273	PETSS	SPOP	0.866	More...
P78312	Protein FAM193A	DEG_SPOP_SBC_1	979:983	PETSS	SPOP	0.9825	More...
P0C874	Spermatogenesis-associated protein 31D3	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.6572	More...
Q5T1A1	DC-STAMP domain-containing protein 2	DEG_SPOP_SBC_1	739:743	PETSS	SPOP	0.9843	More...
Q6ZQQ2	Spermatogenesis-associated protein 31D1	DEG_SPOP_SBC_1	789:793	PETSS	SPOP	0.8868	More...
Q6ZUB0	Spermatogenesis-associated protein 31D4	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.8838	More...
Q9ULG3	Uncharacterized protein CFAP92	DEG_SPOP_SBC_1	276:280	PETSS	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETSS

Degron related mutations and impact score

Drug responses associated with PDZD2 mutations

All proteins holding degron of PETSS