DegronMD

Uniprot ID: P21802

Source protein: Fibroblast growth factor receptor 2

Source gene: FGFR2

Class: DEG_SPOP_SBC_1

Location: 432:436

E3 ligase: SPOP

DEGRON score: 0.9911

ASA_SCORE: 76.84

COIL: 0.8486

CONS_SCORE: 0.482

DSS_SCORE: 0.5641

HELIX: 0.1088

FCONS_SCORE: 1.0214

RIG_SCORE: 0.6435

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S438F	TCGA-D3-A2JH	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	0.2778
p.V446M	TCGA-D5-6530	COAD	TCGA	AESSS	DEG_SPOP_SBC_1	0.0556
p.V446M	DO8312	COAD	ICGC	AESSS	DEG_SPOP_SBC_1	0.0556
p.P444T	TCGA-DA-A1I7	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	0.1111
p.P424S	TCGA-EB-A551	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	0.1111
p.S441F	TCGA-ER-A19N	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	0.1944
p.S441F	DO37452	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	0.1944
p.N440Y	TCGA-EY-A1GU	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	0.6667
p.N440Y	DO41518	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	0.6667
p.N440K	DO229009	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	0.6667
p.S437T	DO222696	MELA	ICGC	AESSS	DEG_SPOP_SBC_1	0.75
p.I423M	SIDM00458	Acute Myeloid Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	0.0833
p.I423M	ACH-000751	Leukemia	CCLE	AESSS	DEG_SPOP_SBC_1	0.0833
p.I423M	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	0.0833
p.I423V	SIDM00537	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.0833
p.I423V	ACH-000982	Colon/Colorectal Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	0.0833
p.I423V	ACH-001345	Colon/Colorectal Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	0.0833
p.I423V	GP5d	large_intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	0.0833
p.R426Q	ACH-002834	Bone Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	0.1667
p.N435K	MFE-296	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	0.6918
p.N435K	AN3-CA	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	0.6918
p.D441N	COLO-679	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	0.1944
p.N432K	MFE-296	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	0.6918
p.N432K	AN3-CA	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	0.6918
p.D445N	COLO-679	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	0.0833
p.K440T	NCI-H630	large_intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	0.6667
p.P443H	SK-OV-3	ovary	COSMIC	AESSS	DEG_SPOP_SBC_1	0.1389
p.D440N	COLO-679	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	0.6667
p.I422V	GP5d	large_intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	0.0556
p.I422M	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	0.0556
p.Y429H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	0.25
p.D443N	COLO-679	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	0.1389
p.N437K	MFE-296	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	0.75
p.N437K	AN3-CA	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	0.75
p.P442H	SK-OV-3	ovary	COSMIC	AESSS	DEG_SPOP_SBC_1	0.6111
p.N434S	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	0.7069
p.P445H	SK-OV-3	ovary	COSMIC	AESSS	DEG_SPOP_SBC_1	0.0833
p.N433K	AN3-CA	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	0.6918
p.N433K	MFE-296	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	0.6918
p.K431E	DJM-1	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	0.3056
p.K431E	EFM-19	breast	COSMIC	AESSS	DEG_SPOP_SBC_1	0.3056
p.I424M	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	0.1111
p.I423S	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	0.0833
p.I424V	GP5d	large_intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	0.1111

Drug responses associated with FGFR2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00795	SKCM\|melanoma	p.E637K (No)	GDSC	PD173074	9.0753
SIDM00795	SKCM\|melanoma	p.E637K (No)	GDSC	AZD4547	6.8187
SIDM00795	SKCM\|melanoma	p.E637K (No)	GDSC	FGFR_3831	6.2336
SIDM00795	SKCM\|melanoma	p.E637K (No)	GDSC	AZD4547	8.0648
SIDM00795	SKCM\|melanoma	p.E637K (No)	GDSC	PD173074	149.5
SIDM00795	SKCM\|melanoma	p.E637K (No)	GDSC	AZD4547	19.75
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G89V (No)	GDSC	PD173074	15.4478
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G89V (No)	GDSC	AZD4547	14.9038
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G89V (No)	GDSC	FGFR_3831	21.6082
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G89V (No)	GDSC	AZD4547	11.9352
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.C809Y (No)	GDSC	PD173074	2.9501
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.C809Y (No)	GDSC	AZD4547	4.0661
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.C809Y (No)	GDSC	FGFR_3831	2.1575
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.C809Y (No)	GDSC	AZD4547	4.1812
SIDM00079	OV\|ovary	p.P560H (No)	GDSC	PD173074	15.0134
SIDM00079	OV\|ovary	p.P560H (No)	GDSC	AZD4547	23.3546
SIDM00079	OV\|ovary	p.P560H (No)	GDSC	FGFR_3831	13.6888
SIDM00079	OV\|ovary	p.P560H (No)	GDSC	AZD4547	1.1566
SIDM00079	OV\|ovary	p.P560H (No)	GDSC	PD173074	498.59
SIDM00079	OV\|ovary	p.P560H (No)	GDSC	AZD4547	125.45
SIDM00901	UCEC\|endometrium	p.N550K (No)	GDSC	PD173074	0.3297
SIDM00901	UCEC\|endometrium	p.N550K (No)	GDSC	AZD4547	0.2756
SIDM00901	UCEC\|endometrium	p.N550K (No)	GDSC	FGFR_3831	4.3993
SIDM00901	UCEC\|endometrium	p.N550K (No)	GDSC	AZD4547	0.2187
SIDM00901	UCEC\|endometrium	p.N550K (No)	GDSC	PD173074	3.7393
SIDM00901	UCEC\|endometrium	p.N550K (No)	GDSC	AZD4547	2.194
SIDM00901	UCEC\|endometrium	p.K310R (No)	GDSC	PD173074	0.3297
SIDM00901	UCEC\|endometrium	p.K310R (No)	GDSC	AZD4547	0.2756
SIDM00901	UCEC\|endometrium	p.K310R (No)	GDSC	FGFR_3831	4.3993
SIDM00901	UCEC\|endometrium	p.K310R (No)	GDSC	AZD4547	0.2187
SIDM00901	UCEC\|endometrium	p.K310R (No)	GDSC	PD173074	3.7393
SIDM00901	UCEC\|endometrium	p.K310R (No)	GDSC	AZD4547	2.194
SIDM00334	UCEC\|endometrium	p.N550K (No)	GDSC	PD173074	1.5588
SIDM00334	UCEC\|endometrium	p.N550K (No)	GDSC	AZD4547	1.0355
SIDM00334	UCEC\|endometrium	p.N550K (No)	GDSC	FGFR_3831	5.5197
SIDM00334	UCEC\|endometrium	p.N550K (No)	GDSC	AZD4547	0.5561
SIDM00334	UCEC\|endometrium	p.N550K (No)	GDSC	PD173074	186.36
SIDM00334	UCEC\|endometrium	p.N550K (No)	GDSC	AZD4547	9.8186
SIDM00353	UNCLASSIFIED\|ovary	p.T341M (No)	GDSC	PD173074	4.7759
SIDM00353	UNCLASSIFIED\|ovary	p.T341M (No)	GDSC	AZD4547	53.7771
SIDM00353	UNCLASSIFIED\|ovary	p.T341M (No)	GDSC	FGFR_3831	12.6745
SIDM00353	UNCLASSIFIED\|ovary	p.T341M (No)	GDSC	AZD4547	11.8122
SIDM00353	UNCLASSIFIED\|ovary	p.T341M (No)	GDSC	PD173074	270.1
SIDM00353	UNCLASSIFIED\|ovary	p.T341M (No)	GDSC	AZD4547	165.78
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.Y328S (No)	GDSC	PD173074	22.836
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.Y328S (No)	GDSC	AZD4547	10.8357
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.Y328S (No)	GDSC	FGFR_3831	22.5485
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.Y328S (No)	GDSC	AZD4547	5.0084
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.Y328S (No)	GDSC	PD173074	68.229
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.Y328S (No)	GDSC	AZD4547	37.662
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.K402R (No)	GDSC	PD173074	32.0121
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.K402R (No)	GDSC	AZD4547	16.0533
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.K402R (No)	GDSC	FGFR_3831	13.524
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.K402R (No)	GDSC	AZD4547	9.0217
SIDM01007	ALL\|lymphoblastic_leukemia	p.M585R (No)	GDSC	PD173074	1.9732
SIDM01007	ALL\|lymphoblastic_leukemia	p.M585R (No)	GDSC	AZD4547	2.1003
SIDM01007	ALL\|lymphoblastic_leukemia	p.M585R (No)	GDSC	FGFR_3831	1.4266
SIDM01007	ALL\|lymphoblastic_leukemia	p.M585R (No)	GDSC	AZD4547	8.6328
SIDM01007	ALL\|lymphoblastic_leukemia	p.M585R (No)	GDSC	PD173074	10.572
SIDM01007	ALL\|lymphoblastic_leukemia	p.M585R (No)	GDSC	AZD4547	4.5386
SIDM00980	STAD\|stomach	p.R251* (No)	GDSC	PD173074	24.4164
SIDM00980	STAD\|stomach	p.R251* (No)	GDSC	AZD4547	10.1726
SIDM00980	STAD\|stomach	p.R251* (No)	GDSC	FGFR_3831	9.2273
SIDM00980	STAD\|stomach	p.R251* (No)	GDSC	AZD4547	3.1431
SIDM00980	STAD\|stomach	p.R251* (No)	GDSC	PD173074	10.301
SIDM00980	STAD\|stomach	p.R251* (No)	GDSC	AZD4547	3.9399
SIDM00393	STAD\|stomach	p.L20V (No)	GDSC	PD173074	28.4884
SIDM00393	STAD\|stomach	p.L20V (No)	GDSC	AZD4547	143.0684
SIDM00393	STAD\|stomach	p.L20V (No)	GDSC	FGFR_3831	9.7354
SIDM00393	STAD\|stomach	p.L20V (No)	GDSC	AZD4547	11.3692
SIDM00393	STAD\|stomach	p.L20V (No)	GDSC	PD173074	55.407
SIDM00393	STAD\|stomach	p.L20V (No)	GDSC	AZD4547	16.061
SIDM01056	BRCA\|breast	p.K660E (No)	GDSC	PD173074	8.6334
SIDM01056	BRCA\|breast	p.K660E (No)	GDSC	AZD4547	35.2886
SIDM01056	BRCA\|breast	p.K660E (No)	GDSC	FGFR_3831	16.5015
SIDM01056	BRCA\|breast	p.K660E (No)	GDSC	AZD4547	3.1694
SIDM01056	BRCA\|breast	p.K660E (No)	GDSC	PD173074	47.757
SIDM01056	BRCA\|breast	p.K660E (No)	GDSC	AZD4547	7.4806
SIDM00126	SKCM\|melanoma	p.G794E (No)	GDSC	PD173074	30.0908
SIDM00126	SKCM\|melanoma	p.G794E (No)	GDSC	AZD4547	128.7396
SIDM00126	SKCM\|melanoma	p.G794E (No)	GDSC	FGFR_3831	205.4182
SIDM00126	SKCM\|melanoma	p.G794E (No)	GDSC	AZD4547	23.7422
SIDM01125	UNCLASSIFIED\|lung_NSCLC_not_specified	p.S454L (No)	GDSC	PD173074	15.1473
SIDM01125	UNCLASSIFIED\|lung_NSCLC_not_specified	p.S454L (No)	GDSC	AZD4547	8.4127
SIDM01125	UNCLASSIFIED\|lung_NSCLC_not_specified	p.S454L (No)	GDSC	FGFR_3831	6.4477
SIDM01125	UNCLASSIFIED\|lung_NSCLC_not_specified	p.S454L (No)	GDSC	AZD4547	4.7278
SIDM01043	UNCLASSIFIED\|endometrium	p.A315T (No)	GDSC	PD173074	8.0169
SIDM01043	UNCLASSIFIED\|endometrium	p.A315T (No)	GDSC	AZD4547	12.263
SIDM01043	UNCLASSIFIED\|endometrium	p.A315T (No)	GDSC	FGFR_3831	4.7997
SIDM01043	UNCLASSIFIED\|endometrium	p.A315T (No)	GDSC	AZD4547	2.0465
SIDM01043	UNCLASSIFIED\|endometrium	p.A315T (No)	GDSC	PD173074	3.7274
SIDM01043	UNCLASSIFIED\|endometrium	p.A315T (No)	GDSC	AZD4547	5.2945
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.G250D (No)	GDSC	PD173074	17.376
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.G250D (No)	GDSC	AZD4547	13.8182
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.G250D (No)	GDSC	FGFR_3831	10.6523
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.G250D (No)	GDSC	AZD4547	12.6268
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.R613T (No)	GDSC	PD173074	32.5031
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.R613T (No)	GDSC	AZD4547	21.4374
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.R613T (No)	GDSC	FGFR_3831	12.0986
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.R613T (No)	GDSC	AZD4547	10.3675
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.R613T (No)	GDSC	PD173074	73.698
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.R613T (No)	GDSC	AZD4547	48.518
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.N663S (No)	GDSC	PD173074	5.7467
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.N663S (No)	GDSC	AZD4547	4.5154
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.N663S (No)	GDSC	FGFR_3831	18.1255
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.N663S (No)	GDSC	AZD4547	4.8344
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.N663S (No)	GDSC	PD173074	30.999
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.N663S (No)	GDSC	AZD4547	6.1336
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.Y658H (No)	GDSC	PD173074	5.7467
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.Y658H (No)	GDSC	AZD4547	4.5154
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.Y658H (No)	GDSC	FGFR_3831	18.1255
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.Y658H (No)	GDSC	AZD4547	4.8344
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.Y658H (No)	GDSC	PD173074	30.999
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.Y658H (No)	GDSC	AZD4547	6.1336
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I652S (No)	GDSC	PD173074	5.7467
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I652S (No)	GDSC	AZD4547	4.5154
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I652S (No)	GDSC	FGFR_3831	18.1255
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I652S (No)	GDSC	AZD4547	4.8344
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I652S (No)	GDSC	PD173074	30.999
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I652S (No)	GDSC	AZD4547	6.1336
SIDM01045	UCEC\|endometrium	p.Y587H (No)	GDSC	PD173074	44.3252
SIDM01045	UCEC\|endometrium	p.Y587H (No)	GDSC	AZD4547	42.1888
SIDM01045	UCEC\|endometrium	p.Y587H (No)	GDSC	FGFR_3831	22.6992
SIDM01045	UCEC\|endometrium	p.Y587H (No)	GDSC	AZD4547	21.9324
SIDM01045	UCEC\|endometrium	p.Y587H (No)	GDSC	PD173074	162.85
SIDM01045	UCEC\|endometrium	p.Y587H (No)	GDSC	AZD4547	89.598
SIDM00335	UCEC\|endometrium	p.S252W (No)	GDSC	PD173074	3.2731
SIDM00335	UCEC\|endometrium	p.S252W (No)	GDSC	AZD4547	142.6762
SIDM00335	UCEC\|endometrium	p.S252W (No)	GDSC	FGFR_3831	1.0268
SIDM00335	UCEC\|endometrium	p.S252W (No)	GDSC	AZD4547	0.1016
SIDM00335	UCEC\|endometrium	p.S252W (No)	GDSC	PD173074	32.409
SIDM00335	UCEC\|endometrium	p.S252W (No)	GDSC	AZD4547	4.6602
SIDM00864	CESC\|cervix	p.G250D (No)	GDSC	PD173074	11.8734
SIDM00864	CESC\|cervix	p.G250D (No)	GDSC	AZD4547	42.4113
SIDM00864	CESC\|cervix	p.G250D (No)	GDSC	FGFR_3831	44.4715
SIDM00864	CESC\|cervix	p.G250D (No)	GDSC	PD173074	100.25
SIDM00864	CESC\|cervix	p.G250D (No)	GDSC	AZD4547	16.989
SIDM00195	UNCLASSIFIED\|ewings_sarcoma	p.Q362R (No)	GDSC	PD173074	22.4401
SIDM00195	UNCLASSIFIED\|ewings_sarcoma	p.Q362R (No)	GDSC	AZD4547	77.4619
SIDM00195	UNCLASSIFIED\|ewings_sarcoma	p.Q362R (No)	GDSC	FGFR_3831	17.2337
SIDM00195	UNCLASSIFIED\|ewings_sarcoma	p.Q362R (No)	GDSC	AZD4547	11.4136
SIDM00195	UNCLASSIFIED\|ewings_sarcoma	p.Q362R (No)	GDSC	PD173074	34.308
SIDM00195	UNCLASSIFIED\|ewings_sarcoma	p.Q362R (No)	GDSC	AZD4547	28.451
SIDM00333	UCEC\|endometrium	p.S252W (No)	GDSC	PD173074	15.6213
SIDM00333	UCEC\|endometrium	p.S252W (No)	GDSC	AZD4547	54.4104
SIDM00333	UCEC\|endometrium	p.S252W (No)	GDSC	FGFR_3831	23.7473
SIDM00333	UCEC\|endometrium	p.S252W (No)	GDSC	AZD4547	10.2047
SIDM00333	UCEC\|endometrium	p.S252W (No)	GDSC	PD173074	86.213
SIDM00333	UCEC\|endometrium	p.S252W (No)	GDSC	AZD4547	9.6793
SIDM00217	COREAD\|large_intestine	p.L452I (No)	GDSC	FGFR_3831	59.9387
SIDM00217	COREAD\|large_intestine	p.L452I (No)	GDSC	AZD4547	23.8098
SIDM00217	COREAD\|large_intestine	p.L452I (No)	GDSC	AZD4547	58.886
SIDM00140	SKCM\|melanoma	p.R6C (No)	GDSC	PD173074	35.9563
SIDM00140	SKCM\|melanoma	p.R6C (No)	GDSC	AZD4547	23.8191
SIDM00140	SKCM\|melanoma	p.R6C (No)	GDSC	FGFR_3831	47.3548
SIDM00140	SKCM\|melanoma	p.R6C (No)	GDSC	AZD4547	4.5991
SIDM00140	SKCM\|melanoma	p.R6C (No)	GDSC	PD173074	75.114
SIDM00140	SKCM\|melanoma	p.R6C (No)	GDSC	AZD4547	4.8212
SIDM00898	BRCA\|breast	p.G365E (No)	GDSC	PD173074	39.4361
SIDM00898	BRCA\|breast	p.G365E (No)	GDSC	AZD4547	47.7853
SIDM00898	BRCA\|breast	p.G365E (No)	GDSC	FGFR_3831	41.1618
SIDM00898	BRCA\|breast	p.G365E (No)	GDSC	PD173074	40.296
SIDM00898	BRCA\|breast	p.G365E (No)	GDSC	AZD4547	23.57
SIDM00216	COREAD\|large_intestine	p.D457Y (No)	GDSC	PD173074	48.945
SIDM00216	COREAD\|large_intestine	p.D457Y (No)	GDSC	AZD4547	8.4295
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.E219K (No)	GDSC	PD173074	18.8895
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.E219K (No)	GDSC	AZD4547	60.0972
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.E219K (No)	GDSC	FGFR_3831	29.9132
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.E219K (No)	GDSC	AZD4547	7.9747
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.E219K (No)	GDSC	PD173074	162.03
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.E219K (No)	GDSC	AZD4547	130.78
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.L552fs*11 (No)	GDSC	PD173074	1.253
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.L552fs*11 (No)	GDSC	AZD4547	1.0583
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.L552fs*11 (No)	GDSC	FGFR_3831	1.6543
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.L552fs*11 (No)	GDSC	AZD4547	0.2387
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.L552fs*11 (No)	GDSC	PD173074	2.6095
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.L552fs*11 (No)	GDSC	AZD4547	0.4422
SIDM00469	PAAD\|pancreas	p.P814T (No)	GDSC	PD173074	14.8407
SIDM00469	PAAD\|pancreas	p.P814T (No)	GDSC	AZD4547	7.0894
SIDM00469	PAAD\|pancreas	p.P814T (No)	GDSC	FGFR_3831	40.7262
SIDM00469	PAAD\|pancreas	p.P814T (No)	GDSC	AZD4547	6.0035
SIDM00469	PAAD\|pancreas	p.P814T (No)	GDSC	PD173074	108.45
SIDM00469	PAAD\|pancreas	p.P814T (No)	GDSC	AZD4547	45.269
SIDM00640	MESO\|mesothelioma	p.T404M (No)	GDSC	PD173074	1.0583
SIDM00640	MESO\|mesothelioma	p.T404M (No)	GDSC	AZD4547	9.8974
SIDM00640	MESO\|mesothelioma	p.T404M (No)	GDSC	FGFR_3831	2.9749
SIDM00640	MESO\|mesothelioma	p.T404M (No)	GDSC	PD173074	2.1761
SIDM00640	MESO\|mesothelioma	p.T404M (No)	GDSC	AZD4547	2.5763
SIDM00281	UNCLASSIFIED\|skin_other	p.K660E (No)	GDSC	PD173074	10.0526
SIDM00281	UNCLASSIFIED\|skin_other	p.K660E (No)	GDSC	AZD4547	131.8633
SIDM00281	UNCLASSIFIED\|skin_other	p.K660E (No)	GDSC	FGFR_3831	22.531
SIDM00281	UNCLASSIFIED\|skin_other	p.K660E (No)	GDSC	AZD4547	10.3946
SIDM00543	SKCM\|melanoma	p.R6P (No)	GDSC	PD173074	11.9939
SIDM00543	SKCM\|melanoma	p.R6P (No)	GDSC	AZD4547	54.6404
SIDM00543	SKCM\|melanoma	p.R6P (No)	GDSC	FGFR_3831	51.6396
SIDM00543	SKCM\|melanoma	p.R6P (No)	GDSC	AZD4547	10.2345
SIDM00543	SKCM\|melanoma	p.R6P (No)	GDSC	PD173074	31.123
SIDM00543	SKCM\|melanoma	p.R6P (No)	GDSC	AZD4547	9.0426
SIDM00882	BRCA\|breast	p.R6P (No)	GDSC	PD173074	52.4789
SIDM00882	BRCA\|breast	p.R6P (No)	GDSC	AZD4547	246.0515
SIDM00882	BRCA\|breast	p.R6P (No)	GDSC	FGFR_3831	238.687
SIDM00882	BRCA\|breast	p.R6P (No)	GDSC	AZD4547	23.4899
SIDM00882	BRCA\|breast	p.R6P (No)	GDSC	PD173074	53.732
SIDM00882	BRCA\|breast	p.R6P (No)	GDSC	AZD4547	2.636
SIDM00783	COREAD\|large_intestine	p.P583L (No)	GDSC	PD173074	10.9811
SIDM00783	COREAD\|large_intestine	p.P583L (No)	GDSC	AZD4547	6.2956
SIDM00783	COREAD\|large_intestine	p.P583L (No)	GDSC	FGFR_3831	7.0145
SIDM00783	COREAD\|large_intestine	p.P583L (No)	GDSC	AZD4547	5.7217
SIDM00783	COREAD\|large_intestine	p.P583L (No)	GDSC	PD173074	19.131
SIDM00783	COREAD\|large_intestine	p.P583L (No)	GDSC	AZD4547	14.346
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.A355S (No)	GDSC	PD173074	45.6603
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.A355S (No)	GDSC	AZD4547	60.3738
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.A355S (No)	GDSC	FGFR_3831	139.6921
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.A355S (No)	GDSC	AZD4547	26.8148
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.A355S (No)	GDSC	PD173074	151.74
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.A355S (No)	GDSC	AZD4547	20.244
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333V (No)	GDSC	PD173074	17.5879
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333V (No)	GDSC	AZD4547	7.0484
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333V (No)	GDSC	FGFR_3831	14.9865
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333V (No)	GDSC	AZD4547	5.5019
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333V (No)	GDSC	PD173074	9.2098
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333V (No)	GDSC	AZD4547	6.9866
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333T (No)	GDSC	PD173074	17.5879
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333T (No)	GDSC	AZD4547	7.0484
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333T (No)	GDSC	FGFR_3831	14.9865
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333T (No)	GDSC	AZD4547	5.5019
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333T (No)	GDSC	PD173074	9.2098
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A333T (No)	GDSC	AZD4547	6.9866
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.K540* (No)	GDSC	PD173074	35.4394
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.K540* (No)	GDSC	AZD4547	24.069
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.K540* (No)	GDSC	FGFR_3831	25.2623
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.K540* (No)	GDSC	AZD4547	15.6696
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.K540* (No)	GDSC	PD173074	35.929
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.K540* (No)	GDSC	AZD4547	59.455
SIDM00458	LAML\|acute_myeloid_leukaemia	p.I423M (Yes)	GDSC	PD173074	7.05
SIDM00458	LAML\|acute_myeloid_leukaemia	p.I423M (Yes)	GDSC	AZD4547	23.5484
SIDM00458	LAML\|acute_myeloid_leukaemia	p.I423M (Yes)	GDSC	FGFR_3831	41.0517
SIDM00458	LAML\|acute_myeloid_leukaemia	p.I423M (Yes)	GDSC	AZD4547	4.8442
SIDM00458	LAML\|acute_myeloid_leukaemia	p.I423M (Yes)	GDSC	PD173074	39.421
SIDM00458	LAML\|acute_myeloid_leukaemia	p.I423M (Yes)	GDSC	AZD4547	3.5388
SIDM00866	BRCA\|breast	p.R203C (No)	GDSC	PD173074	21.5914
SIDM00866	BRCA\|breast	p.R203C (No)	GDSC	AZD4547	119.8307
SIDM00866	BRCA\|breast	p.R203C (No)	GDSC	FGFR_3831	22.3259
SIDM00866	BRCA\|breast	p.R203C (No)	GDSC	AZD4547	21.2458
SIDM00866	BRCA\|breast	p.R203C (No)	GDSC	PD173074	188.21
SIDM00866	BRCA\|breast	p.R203C (No)	GDSC	AZD4547	49.245
SIDM00789	COREAD\|large_intestine	p.T362M (No)	GDSC	PD173074	38.7562
SIDM00789	COREAD\|large_intestine	p.T362M (No)	GDSC	AZD4547	23.8868
SIDM00789	COREAD\|large_intestine	p.T362M (No)	GDSC	FGFR_3831	142.4222
SIDM00789	COREAD\|large_intestine	p.T362M (No)	GDSC	PD173074	37.283
SIDM00789	COREAD\|large_intestine	p.T362M (No)	GDSC	AZD4547	10.021
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S620F (No)	GDSC	PD173074	74.0172
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S620F (No)	GDSC	AZD4547	427.9494
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S620F (No)	GDSC	FGFR_3831	234.6272
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S620F (No)	GDSC	AZD4547	31.6269
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S620F (No)	GDSC	PD173074	409.48
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S620F (No)	GDSC	AZD4547	255.6
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R178C (No)	GDSC	PD173074	74.0172
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R178C (No)	GDSC	AZD4547	427.9494
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R178C (No)	GDSC	FGFR_3831	234.6272
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R178C (No)	GDSC	AZD4547	31.6269
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R178C (No)	GDSC	PD173074	409.48
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R178C (No)	GDSC	AZD4547	255.6
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.E367K (No)	GDSC	PD173074	12.6873
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.E367K (No)	GDSC	AZD4547	31.9529
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.E367K (No)	GDSC	FGFR_3831	20.091
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.E367K (No)	GDSC	AZD4547	7.3487
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.E367K (No)	GDSC	PD173074	39.492
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.E367K (No)	GDSC	AZD4547	6.7255
SIDM00545	SKCM\|melanoma	p.E163K (No)	GDSC	PD173074	29.2317
SIDM00545	SKCM\|melanoma	p.E163K (No)	GDSC	AZD4547	25.5196
SIDM00545	SKCM\|melanoma	p.E163K (No)	GDSC	FGFR_3831	44.162
SIDM00545	SKCM\|melanoma	p.E163K (No)	GDSC	AZD4547	19.2645
SIDM00545	SKCM\|melanoma	p.E163K (No)	GDSC	PD173074	86.925
SIDM00545	SKCM\|melanoma	p.E163K (No)	GDSC	AZD4547	128.05
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.R6P (No)	GDSC	PD173074	36.8537
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.R6P (No)	GDSC	AZD4547	121.9135
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.R6P (No)	GDSC	FGFR_3831	10.9105
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.R6P (No)	GDSC	AZD4547	4.7275
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.R6P (No)	GDSC	PD173074	111.47
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.R6P (No)	GDSC	AZD4547	110.13
SIDM00537	COREAD\|large_intestine	p.I423V (Yes)	GDSC	PD173074	18.9676
SIDM00537	COREAD\|large_intestine	p.I423V (Yes)	GDSC	AZD4547	43.8346
SIDM00537	COREAD\|large_intestine	p.I423V (Yes)	GDSC	FGFR_3831	23.8792
SIDM00537	COREAD\|large_intestine	p.I423V (Yes)	GDSC	AZD4547	8.993
SIDM00537	COREAD\|large_intestine	p.I423V (Yes)	GDSC	PD173074	22.3
SIDM00537	COREAD\|large_intestine	p.I423V (Yes)	GDSC	AZD4547	65.347
SIDM00457	MM\|myeloma	p.R6P (No)	GDSC	PD173074	0.5689
SIDM00457	MM\|myeloma	p.R6P (No)	GDSC	AZD4547	0.679
SIDM00457	MM\|myeloma	p.R6P (No)	GDSC	FGFR_3831	11.609
SIDM00457	MM\|myeloma	p.R6P (No)	GDSC	AZD4547	1.5178
SIDM00457	MM\|myeloma	p.R6P (No)	GDSC	PD173074	0.5241
SIDM00457	MM\|myeloma	p.R6P (No)	GDSC	AZD4547	0.2715
SIDM01027	ESCA\|oesophagus	p.R6P (No)	GDSC	PD173074	15.7086
SIDM01027	ESCA\|oesophagus	p.R6P (No)	GDSC	AZD4547	45.3352
SIDM01027	ESCA\|oesophagus	p.R6P (No)	GDSC	FGFR_3831	24.468
SIDM01027	ESCA\|oesophagus	p.R6P (No)	GDSC	PD173074	117.99
SIDM01027	ESCA\|oesophagus	p.R6P (No)	GDSC	AZD4547	30.863
SIDM00054	PAAD\|pancreas	p.F646V (No)	GDSC	PD173074	2.1542
SIDM00054	PAAD\|pancreas	p.F646V (No)	GDSC	AZD4547	68.1433
SIDM00054	PAAD\|pancreas	p.F646V (No)	GDSC	FGFR_3831	14.0399
SIDM00054	PAAD\|pancreas	p.F646V (No)	GDSC	PD173074	183.59
SIDM00054	PAAD\|pancreas	p.F646V (No)	GDSC	AZD4547	93.778
SIDM00571	UNCLASSIFIED\|pancreas	p.R6P (No)	GDSC	PD173074	39.2419
SIDM00571	UNCLASSIFIED\|pancreas	p.R6P (No)	GDSC	AZD4547	16.4537
SIDM00571	UNCLASSIFIED\|pancreas	p.R6P (No)	GDSC	FGFR_3831	127.3352
SIDM00571	UNCLASSIFIED\|pancreas	p.R6P (No)	GDSC	AZD4547	11.6037
SIDM00571	UNCLASSIFIED\|pancreas	p.R6P (No)	GDSC	PD173074	366.09
SIDM00571	UNCLASSIFIED\|pancreas	p.R6P (No)	GDSC	AZD4547	137.07
SIDM00284	SKCM\|melanoma	p.D558N (No)	GDSC	PD173074	22.7777
SIDM00284	SKCM\|melanoma	p.D558N (No)	GDSC	AZD4547	64.2543
SIDM00284	SKCM\|melanoma	p.D558N (No)	GDSC	FGFR_3831	19.4826
SIDM00284	SKCM\|melanoma	p.D558N (No)	GDSC	AZD4547	6.6418
SIDM00284	SKCM\|melanoma	p.D558N (No)	GDSC	PD173074	102.12
SIDM00284	SKCM\|melanoma	p.D558N (No)	GDSC	AZD4547	52.376
SIDM00118	COREAD\|large_intestine	p.D796E (No)	GDSC	PD173074	6.549
SIDM00118	COREAD\|large_intestine	p.D796E (No)	GDSC	AZD4547	18.328
SIDM00118	COREAD\|large_intestine	p.D796E (No)	GDSC	FGFR_3831	110.0369
SIDM00118	COREAD\|large_intestine	p.D796E (No)	GDSC	AZD4547	9.1547
SIDM00118	COREAD\|large_intestine	p.D796E (No)	GDSC	PD173074	44.098
SIDM00118	COREAD\|large_intestine	p.D796E (No)	GDSC	AZD4547	23.708
SIDM00118	COREAD\|large_intestine	p.Q361R (No)	GDSC	PD173074	6.549
SIDM00118	COREAD\|large_intestine	p.Q361R (No)	GDSC	AZD4547	18.328
SIDM00118	COREAD\|large_intestine	p.Q361R (No)	GDSC	FGFR_3831	110.0369
SIDM00118	COREAD\|large_intestine	p.Q361R (No)	GDSC	AZD4547	9.1547
SIDM00118	COREAD\|large_intestine	p.Q361R (No)	GDSC	PD173074	44.098
SIDM00118	COREAD\|large_intestine	p.Q361R (No)	GDSC	AZD4547	23.708

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D2B8	Putative postmeiotic segregation increased 2-like protein 1	DEG_SPOP_SBC_1	204:208	AESSS	SPOP	0.7952	More...
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	39:43	AESSS	SPOP	0.9974	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	531:535	AESSS	SPOP	0.9433	More...
O75140	GATOR complex protein DEPDC5	DEG_SPOP_SBC_1	1071:1075	AESSS	SPOP	0.994	More...
O95425	Supervillin	DEG_SPOP_SBC_1	224:228	AESSS	SPOP	0.9913	More...
P21127	Cyclin-dependent kinase 11B	DEG_SPOP_SBC_1	292:296	AESSS	SPOP	0.9672	More...
P21802	Fibroblast growth factor receptor 2	DEG_SPOP_SBC_1	432:436	AESSS	SPOP	0.9911	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	509:513	AESSS	SPOP	0.6044	More...
Q02410	Amyloid-beta A4 precursor protein-binding family A member 1	DEG_SPOP_SBC_1	412:416	AESSS	SPOP	0.8001	More...
Q0JRZ9	F-BAR domain only protein 2	DEG_SPOP_SBC_1	506:510	AESSS	SPOP	0.9995	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	218:222	AESSS	SPOP	0.504	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	1450:1454	AESSS	SPOP	0.9979	More...
Q14978	Nucleolar and coiled-body phosphoprotein 1	DEG_SPOP_SBC_1	359:363	AESSS	SPOP	0.9466	More...
Q15054	DNA polymerase delta subunit 3	DEG_SPOP_SBC_1	146:150	AESSS	SPOP	0.8262	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	3437:3441	AESSS	SPOP	0.631	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	2039:2043	AESSS	SPOP	0.9996	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	4995:4999	AESSS	SPOP	0.9626	More...
Q63ZY3	KN motif and ankyrin repeat domain-containing protein 2	DEG_SPOP_SBC_1	423:427	AESSS	SPOP	0.9784	More...
Q68EM7	Rho GTPase-activating protein 17	DEG_SPOP_SBC_1	549:553	AESSS	SPOP	0.9662	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	416:420	AESSS	SPOP	0.8744	More...
Q8IVF5	Rho guanine nucleotide exchange factor TIAM2	DEG_SPOP_SBC_1	483:487	AESSS	SPOP	0.8917	More...
Q8IVL1	Neuron navigator 2	DEG_SPOP_SBC_1	712:716	AESSS	SPOP	0.6639	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	327:331	AESSS	SPOP	0.9547	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	877:881	AESSS	SPOP	0.7427	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10859:10863	AESSS	SPOP	0.9546	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11301:11305	AESSS	SPOP	0.5459	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	346:350	AESSS	SPOP	0.9802	More...
Q96FF9	Sororin	DEG_SPOP_SBC_1	122:126	AESSS	SPOP	0.5091	More...
Q9BRP0	Transcription factor Ovo-like 2	DEG_SPOP_SBC_1	68:72	AESSS	SPOP	0.7978	More...
Q9H4L7	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	DEG_SPOP_SBC_1	243:247	AESSS	SPOP	0.9849	More...
Q9UL62	Short transient receptor potential channel 5	DEG_SPOP_SBC_1	829:833	AESSS	SPOP	0.9986	More...
Q9UQ88	Cyclin-dependent kinase 11A	DEG_SPOP_SBC_1	280:284	AESSS	SPOP	0.9779	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1356:1360	AESSS	SPOP	0.9966	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	446:450	AESSS	SPOP	0.8361	More...
Q6ZU80	Centrosomal protein of 128 kDa	DEG_SPOP_SBC_1	2:6	AESSS	SPOP	0.5106	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	255:259	AESSS	SPOP	0.9947	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	318:322	AESSS	SPOP	0.8116	More...
Q6NV74	CRACD-like protein	DEG_SPOP_SBC_1	213:217	AESSS	SPOP	0.8849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AESSS

Degron related mutations and impact score

Drug responses associated with FGFR2 mutations

All proteins holding degron of AESSS