DegronMD

Uniprot ID: Q68EM7

Source protein: Rho GTPase-activating protein 17

Source gene: ARHGAP17

Class: DEG_SPOP_SBC_1

Location: 549:553

E3 ligase: SPOP

DEGRON score: 0.9662

ASA_SCORE: 84.58

COIL: 0.9356

CONS_SCORE: 0.3414

DSS_SCORE: 0.8551

HELIX: 0.0524

FCONS_SCORE: 0.9572

RIG_SCORE: 0.4968

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S551R	TCGA-36-2534	OV	TCGA	AESSS	DEG_SPOP_SBC_1	0.7427
p.S551R	DO29046	OV	ICGC	AESSS	DEG_SPOP_SBC_1	0.7427
p.P542L	TCGA-55-8507	LUAD	TCGA	AESSS	DEG_SPOP_SBC_1	0.1389
p.P542L	DO45412	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	0.1389
p.S561F	TCGA-AN-A0FL	BRCA	TCGA	AESSS	DEG_SPOP_SBC_1	0.1111
p.S561F	DO1836	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	0.1111
p.A562T	TCGA-AX-A1CE	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	0.0833
p.A562T	DO42280	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	0.0833
p.S553F	TCGA-CR-6481	HNSC	TCGA	AESSS	DEG_SPOP_SBC_1	0.7982
p.S553F	DO14990	HNSC	ICGC	AESSS	DEG_SPOP_SBC_1	0.7982
p.P540L	TCGA-MT-A67D	HNSC	TCGA	AESSS	DEG_SPOP_SBC_1	0.0833
p.P540L	DO49064	HNSC	ICGC	AESSS	DEG_SPOP_SBC_1	0.0833
p.G539S	TCGA-NC-A5HI	LUSC	TCGA	AESSS	DEG_SPOP_SBC_1	0.0556
p.G539S	DO45461	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	0.0556
p.P543S	DO222390	MELA	ICGC	AESSS	DEG_SPOP_SBC_1	0.1667
p.A562V	SIDM00435	Acute Myeloid Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	0.0833
p.A562V	SIDM00617	Hepatocellular Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.0833
p.A562V	SIDM00352	Ovarian Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.0833
p.A562V	SIDM00860	Head and Neck Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.0833
p.A562V	SIDM00274	Gastric Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.0833
p.A562V	SIDM01609	Endometrial Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.0833
p.A562V	SIDM00062	Hepatocellular Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.0833
p.R552H	SNU-C5	large_intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	0.8244
p.V555I	NCI-H720	lung	COSMIC	AESSS	DEG_SPOP_SBC_1	0.2778
p.A561S	SNU-1040	large_intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D2B8	Putative postmeiotic segregation increased 2-like protein 1	DEG_SPOP_SBC_1	204:208	AESSS	SPOP	0.7952	More...
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	39:43	AESSS	SPOP	0.9974	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	531:535	AESSS	SPOP	0.9433	More...
O75140	GATOR complex protein DEPDC5	DEG_SPOP_SBC_1	1071:1075	AESSS	SPOP	0.994	More...
O95425	Supervillin	DEG_SPOP_SBC_1	224:228	AESSS	SPOP	0.9913	More...
P21127	Cyclin-dependent kinase 11B	DEG_SPOP_SBC_1	292:296	AESSS	SPOP	0.9672	More...
P21802	Fibroblast growth factor receptor 2	DEG_SPOP_SBC_1	432:436	AESSS	SPOP	0.9911	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	509:513	AESSS	SPOP	0.6044	More...
Q02410	Amyloid-beta A4 precursor protein-binding family A member 1	DEG_SPOP_SBC_1	412:416	AESSS	SPOP	0.8001	More...
Q0JRZ9	F-BAR domain only protein 2	DEG_SPOP_SBC_1	506:510	AESSS	SPOP	0.9995	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	218:222	AESSS	SPOP	0.504	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	1450:1454	AESSS	SPOP	0.9979	More...
Q14978	Nucleolar and coiled-body phosphoprotein 1	DEG_SPOP_SBC_1	359:363	AESSS	SPOP	0.9466	More...
Q15054	DNA polymerase delta subunit 3	DEG_SPOP_SBC_1	146:150	AESSS	SPOP	0.8262	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	3437:3441	AESSS	SPOP	0.631	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	2039:2043	AESSS	SPOP	0.9996	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	4995:4999	AESSS	SPOP	0.9626	More...
Q63ZY3	KN motif and ankyrin repeat domain-containing protein 2	DEG_SPOP_SBC_1	423:427	AESSS	SPOP	0.9784	More...
Q68EM7	Rho GTPase-activating protein 17	DEG_SPOP_SBC_1	549:553	AESSS	SPOP	0.9662	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	416:420	AESSS	SPOP	0.8744	More...
Q8IVF5	Rho guanine nucleotide exchange factor TIAM2	DEG_SPOP_SBC_1	483:487	AESSS	SPOP	0.8917	More...
Q8IVL1	Neuron navigator 2	DEG_SPOP_SBC_1	712:716	AESSS	SPOP	0.6639	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	327:331	AESSS	SPOP	0.9547	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	877:881	AESSS	SPOP	0.7427	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10859:10863	AESSS	SPOP	0.9546	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11301:11305	AESSS	SPOP	0.5459	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	346:350	AESSS	SPOP	0.9802	More...
Q96FF9	Sororin	DEG_SPOP_SBC_1	122:126	AESSS	SPOP	0.5091	More...
Q9BRP0	Transcription factor Ovo-like 2	DEG_SPOP_SBC_1	68:72	AESSS	SPOP	0.7978	More...
Q9H4L7	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	DEG_SPOP_SBC_1	243:247	AESSS	SPOP	0.9849	More...
Q9UL62	Short transient receptor potential channel 5	DEG_SPOP_SBC_1	829:833	AESSS	SPOP	0.9986	More...
Q9UQ88	Cyclin-dependent kinase 11A	DEG_SPOP_SBC_1	280:284	AESSS	SPOP	0.9779	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1356:1360	AESSS	SPOP	0.9966	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	446:450	AESSS	SPOP	0.8361	More...
Q6ZU80	Centrosomal protein of 128 kDa	DEG_SPOP_SBC_1	2:6	AESSS	SPOP	0.5106	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	255:259	AESSS	SPOP	0.9947	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	318:322	AESSS	SPOP	0.8116	More...
Q6NV74	CRACD-like protein	DEG_SPOP_SBC_1	213:217	AESSS	SPOP	0.8849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AESSS

Degron related mutations and impact score

Drug responses associated with ARHGAP17 mutations

All proteins holding degron of AESSS