DegronMD

Uniprot ID: Q8NFG4

Source protein: Folliculin

Source gene: FLCN

Class: DEG_SPOP_SBC_1

Location: 327:331

E3 ligase: SPOP

DEGRON score: 0.9547

ASA_SCORE: 66

COIL: 0.8202

CONS_SCORE: 0.2871

DSS_SCORE: 0.6144

HELIX: 0.1224

FCONS_SCORE: 0.9145

RIG_SCORE: 0.6052

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P326Q	TCGA-53-7626	LUAD	TCGA	AESSS	DEG_SPOP_SBC_1	0.3056
p.P326Q	DO23774	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	0.3056
p.P326S	TCGA-EE-A2GO	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	0.3056
p.P326S	DO37823	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	0.3056
p.L319P	DO8786	COAD	ICGC	AESSS	DEG_SPOP_SBC_1	0.1111
p.P326L	DO234199	ESAD	ICGC	AESSS	DEG_SPOP_SBC_1	0.3056
p.R320K	DO222564	ESCA	ICGC	AESSS	DEG_SPOP_SBC_1	0.1389
p.A324T	DO233888	GACA	ICGC	AESSS	DEG_SPOP_SBC_1	0.25
p.A324T	DO42280	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	0.25
p.A324T	SIDM01278	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.25
p.E321D	DO11016	GBM	ICGC	AESSS	DEG_SPOP_SBC_1	0.1667
p.E321D	DO47299	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	0.1667
p.S341P	DO22237	LGG	ICGC	AESSS	DEG_SPOP_SBC_1	0.0556
p.S318L	DO45526	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	0.0833
p.R334W	DO233293	NACA	ICGC	AESSS	DEG_SPOP_SBC_1	0.25
p.R334W	DO50075	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	0.25
p.P338S	DO47368	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	0.1389
p.R320W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	0.1389
p.R320W	ACH-000995	Leukemia	CCLE	AESSS	DEG_SPOP_SBC_1	0.1389
p.R320W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	0.1389
p.S331F	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.7982
p.S331F	JEKO-1	haematopoietic_and_lymphoid_tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	0.7982
p.R330I	SIDM00402	Bladder Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.8102
p.R330I	RT-112	urinary_tract	COSMIC	AESSS	DEG_SPOP_SBC_1	0.8102
p.T331M	SIDM00849	Kidney Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.7423
p.G334C	ACH-000941	Endometrial/Uterine Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D2B8	Putative postmeiotic segregation increased 2-like protein 1	DEG_SPOP_SBC_1	204:208	AESSS	SPOP	0.7952	More...
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	39:43	AESSS	SPOP	0.9974	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	531:535	AESSS	SPOP	0.9433	More...
O75140	GATOR complex protein DEPDC5	DEG_SPOP_SBC_1	1071:1075	AESSS	SPOP	0.994	More...
O95425	Supervillin	DEG_SPOP_SBC_1	224:228	AESSS	SPOP	0.9913	More...
P21127	Cyclin-dependent kinase 11B	DEG_SPOP_SBC_1	292:296	AESSS	SPOP	0.9672	More...
P21802	Fibroblast growth factor receptor 2	DEG_SPOP_SBC_1	432:436	AESSS	SPOP	0.9911	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	509:513	AESSS	SPOP	0.6044	More...
Q02410	Amyloid-beta A4 precursor protein-binding family A member 1	DEG_SPOP_SBC_1	412:416	AESSS	SPOP	0.8001	More...
Q0JRZ9	F-BAR domain only protein 2	DEG_SPOP_SBC_1	506:510	AESSS	SPOP	0.9995	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	218:222	AESSS	SPOP	0.504	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	1450:1454	AESSS	SPOP	0.9979	More...
Q14978	Nucleolar and coiled-body phosphoprotein 1	DEG_SPOP_SBC_1	359:363	AESSS	SPOP	0.9466	More...
Q15054	DNA polymerase delta subunit 3	DEG_SPOP_SBC_1	146:150	AESSS	SPOP	0.8262	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	3437:3441	AESSS	SPOP	0.631	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	2039:2043	AESSS	SPOP	0.9996	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	4995:4999	AESSS	SPOP	0.9626	More...
Q63ZY3	KN motif and ankyrin repeat domain-containing protein 2	DEG_SPOP_SBC_1	423:427	AESSS	SPOP	0.9784	More...
Q68EM7	Rho GTPase-activating protein 17	DEG_SPOP_SBC_1	549:553	AESSS	SPOP	0.9662	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	416:420	AESSS	SPOP	0.8744	More...
Q8IVF5	Rho guanine nucleotide exchange factor TIAM2	DEG_SPOP_SBC_1	483:487	AESSS	SPOP	0.8917	More...
Q8IVL1	Neuron navigator 2	DEG_SPOP_SBC_1	712:716	AESSS	SPOP	0.6639	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	327:331	AESSS	SPOP	0.9547	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	877:881	AESSS	SPOP	0.7427	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10859:10863	AESSS	SPOP	0.9546	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11301:11305	AESSS	SPOP	0.5459	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	346:350	AESSS	SPOP	0.9802	More...
Q96FF9	Sororin	DEG_SPOP_SBC_1	122:126	AESSS	SPOP	0.5091	More...
Q9BRP0	Transcription factor Ovo-like 2	DEG_SPOP_SBC_1	68:72	AESSS	SPOP	0.7978	More...
Q9H4L7	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	DEG_SPOP_SBC_1	243:247	AESSS	SPOP	0.9849	More...
Q9UL62	Short transient receptor potential channel 5	DEG_SPOP_SBC_1	829:833	AESSS	SPOP	0.9986	More...
Q9UQ88	Cyclin-dependent kinase 11A	DEG_SPOP_SBC_1	280:284	AESSS	SPOP	0.9779	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1356:1360	AESSS	SPOP	0.9966	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	446:450	AESSS	SPOP	0.8361	More...
Q6ZU80	Centrosomal protein of 128 kDa	DEG_SPOP_SBC_1	2:6	AESSS	SPOP	0.5106	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	255:259	AESSS	SPOP	0.9947	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	318:322	AESSS	SPOP	0.8116	More...
Q6NV74	CRACD-like protein	DEG_SPOP_SBC_1	213:217	AESSS	SPOP	0.8849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AESSS

Degron related mutations and impact score

Drug responses associated with FLCN mutations

All proteins holding degron of AESSS