DegronMD - Q0JRZ9(FCHO2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S508I	TCGA-09-2044	OV	TCGA	AESSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.8453
p.S508I	DO28923	OV	ICGC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.8453
p.S509Y	TCGA-AA-3977	COAD	TCGA	AESSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.8231
p.S509Y	DO8730	COAD	ICGC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.8231
p.D311Y	TCGA-AJ-A5DW	UCEC	TCGA	DVDEEGYSIKP	CBL_PTK	317:327	Mutation rewiring degron network	0.1667
p.D311Y	DO229036	LICA	ICGC	DVDEEGYSIKP	CBL_PTK	317:327	Mutation rewiring degron network	0.1667
p.D311Y	DO50075	UCEC	ICGC	DVDEEGYSIKP	CBL_PTK	317:327	Mutation rewiring degron network	0.1667
p.V318A	TCGA-AX-A3FS	UCEC	TCGA	DVDEEGYSIKP	CBL_PTK	317:327	Mutation altering degron motif	0.5825
p.V318A	DO40879	UCEC	ICGC	DVDEEGYSIKP	CBL_PTK	317:327	Mutation altering degron motif	0.5825
p.C307R	TCGA-B5-A1MX	UCEC	TCGA	DVDEEGYSIKP	CBL_PTK	317:327	Mutation rewiring degron network	0.0556
p.C307R	DO41999	UCEC	ICGC	DVDEEGYSIKP	CBL_PTK	317:327	Mutation rewiring degron network	0.0556
p.R505L	DO228978	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.3056
p.R505L	DO229036	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.3056
p.C307F	DO229036	LICA	ICGC	DVDEEGYSIKP	CBL_PTK	317:327	Mutation rewiring degron network	0.0556
p.E320Q	DO233292	NACA	ICGC	DVDEEGYSIKP	CBL_PTK	317:327	Mutation altering degron motif	0.5633
p.N330K	DO233299	NACA	ICGC	DVDEEGYSIKP	CBL_PTK	317:327	Mutation rewiring degron network	0.25
p.A516V	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1667
p.A516V	SIDM01233	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1667
p.A516V	SIDM00312	Plasma Cell Myeloma	GDSC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1667
p.A516V	SIDM00534	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1667
p.A516V	SIDM00387	Neuroblastoma	GDSC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1667
p.A500T	SIDM00845	Burkitt's Lymphoma	GDSC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1667
p.A506V	SIDM00789	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.5825
p.A506V	ACH-000997	Colon/Colorectal Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.5825
p.A506V	ACH-001061	Colon/Colorectal Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.5825
p.A506V	HCT-15	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.5825
p.S308L	H2803	pleura	COSMIC	DVDEEGYSIKP	CBL_PTK	317:327	Mutation rewiring degron network	0.0833
p.S309P	SNU-1040	large intestine	COSMIC	DVDEEGYSIKP	CBL_PTK	317:327	Mutation rewiring degron network	0.1111

Kaplan plot for FCHO2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FCHO2

UniProt ID: Q0JRZ9

Entrez ID: 115548

Protein name: F-BAR domain only protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FCHO2 in