DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DVDEEGYSIKP
Uniprot ID:
Q0JRZ9
Source protein:
F-BAR domain only protein 2
Source gene:
FCHO2
Class:
CBL_PTK
Location:
317:327
E3 ligase:
CBL
DEGRON score:
0.9993
ASA_SCORE:
75.1455
COIL:
0.7686
CONS_SCORE:
0.3647
DSS_SCORE:
0.647
HELIX:
0.0864
FCONS_SCORE:
1.3816
RIG_SCORE:
0.7084
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D311Y
TCGA-AJ-A5DW
UCEC
TCGA
DVDEEGYSIKP
CBL_PTK
0.1667
p.D311Y
DO229036
LICA
ICGC
DVDEEGYSIKP
CBL_PTK
0.1667
p.D311Y
DO50075
UCEC
ICGC
DVDEEGYSIKP
CBL_PTK
0.1667
p.V318A
TCGA-AX-A3FS
UCEC
TCGA
DVDEEGYSIKP
CBL_PTK
0.5825
p.V318A
DO40879
UCEC
ICGC
DVDEEGYSIKP
CBL_PTK
0.5825
p.C307R
TCGA-B5-A1MX
UCEC
TCGA
DVDEEGYSIKP
CBL_PTK
0.0556
p.C307R
DO41999
UCEC
ICGC
DVDEEGYSIKP
CBL_PTK
0.0556
p.C307F
DO229036
LICA
ICGC
DVDEEGYSIKP
CBL_PTK
0.0556
p.E320Q
DO233292
NACA
ICGC
DVDEEGYSIKP
CBL_PTK
0.5633
p.N330K
DO233299
NACA
ICGC
DVDEEGYSIKP
CBL_PTK
0.25
p.S308L
H2803
pleura
COSMIC
DVDEEGYSIKP
CBL_PTK
0.0833
p.S309P
SNU-1040
large_intestine
COSMIC
DVDEEGYSIKP
CBL_PTK
0.1111
Drug responses associated with FCHO2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DVDEEGYSIKP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q0JRZ9
F-BAR domain only protein 2
CBL_PTK
317:327
DVDEEGYSIKP
CBL
0.9993
More...