DegronMD

Uniprot ID: Q9Y4G8

Source protein: Rap guanine nucleotide exchange factor 2

Source gene: RAPGEF2

Class: LIG_APCC_ABBA_1

Location: 1165:1170

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8729

ASA_SCORE: 83.2667

COIL: 0.6935

CONS_SCORE: 0.314

DSS_SCORE: 0.4818

HELIX: 0.269

FCONS_SCORE: 0.9708

RIG_SCORE: 0.6976

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1163L	TCGA-44-2656	LUAD	TCGA	VSLHDE	LIG_APCC_ABBA_1	0.2778
p.V1163L	DO26052	LUAD	ICGC	VSLHDE	LIG_APCC_ABBA_1	0.2778
p.R1172H	TCGA-93-A4JQ	LUAD	TCGA	VSLHDE	LIG_APCC_ABBA_1	0.2778
p.R1172H	TCGA-A5-A0G2	UCEC	TCGA	VSLHDE	LIG_APCC_ABBA_1	0.2778
p.R1172H	DO51195	LUAD	ICGC	VSLHDE	LIG_APCC_ABBA_1	0.2778
p.R1172H	DO41235	UCEC	ICGC	VSLHDE	LIG_APCC_ABBA_1	0.2778
p.S1158L	TCGA-AG-A002	READ	TCGA	VSLHDE	LIG_APCC_ABBA_1	0.1389
p.S1158L	TCGA-AX-A06F	UCEC	TCGA	VSLHDE	LIG_APCC_ABBA_1	0.1389
p.S1158L	TCGA-AX-A0J0	UCEC	TCGA	VSLHDE	LIG_APCC_ABBA_1	0.1389
p.S1158L	DO41752	UCEC	ICGC	VSLHDE	LIG_APCC_ABBA_1	0.1389
p.S1158L	DO41133	UCEC	ICGC	VSLHDE	LIG_APCC_ABBA_1	0.1389
p.V1165F	DO228952	LICA	ICGC	VSLHDE	LIG_APCC_ABBA_1	0.5957
p.V1155F	DO229026	LICA	ICGC	VSLHDE	LIG_APCC_ABBA_1	0.0556
p.H1168R	SIDM01617	Endometrial Carcinoma	GDSC	VSLHDE	LIG_APCC_ABBA_1	0.8244
p.H1168R	ACH-000994	Endometrial/Uterine Cancer	CCLE	VSLHDE	LIG_APCC_ABBA_1	0.8244
p.R1172G	ACH-001347	Head and Neck Cancer	CCLE	VSLHDE	LIG_APCC_ABBA_1	0.2778
p.P1178Q	LS-411N	large_intestine	COSMIC	VSLHDE	LIG_APCC_ABBA_1	0.5556
p.N1165S	Hs766T	pancreas	COSMIC	VSLHDE	LIG_APCC_ABBA_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4G8	Rap guanine nucleotide exchange factor 2	LIG_APCC_ABBA_1	1165:1170	VSLHDE	APC,CDC20,FZR1	0.8729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons