DegronMD

Uniprot ID: A4UGR9

Source protein: Xin actin-binding repeat-containing protein 2

Source gene: XIRP2

Class: DEG_SPOP_SBC_1

Location: 258:262

E3 ligase: SPOP

DEGRON score: 0.8479

ASA_SCORE: 73.42

COIL: 0.777

CONS_SCORE: 0.4093

DSS_SCORE: 0.521

HELIX: 0.155

FCONS_SCORE: 1.0514

RIG_SCORE: 0.6962

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E263K	TCGA-86-8278	LUAD	TCGA	VTSST	DEG_SPOP_SBC_1	0.3056
p.E263K	DO26308	LUAD	ICGC	VTSST	DEG_SPOP_SBC_1	0.3056
p.A256V	TCGA-99-8025	LUAD	TCGA	VTSST	DEG_SPOP_SBC_1	0.2778
p.A256V	DO24255	LUAD	ICGC	VTSST	DEG_SPOP_SBC_1	0.2778
p.M248V	TCGA-A8-A09Q	BRCA	TCGA	VTSST	DEG_SPOP_SBC_1	0.0556
p.M248V	DO1579	BRCA	ICGC	VTSST	DEG_SPOP_SBC_1	0.0556
p.E265K	TCGA-AX-A2HC	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	0.25
p.E265K	TCGA-ER-A2NC	SKCM	TCGA	VTSST	DEG_SPOP_SBC_1	0.25
p.E265K	DO47318	SKCM	ICGC	VTSST	DEG_SPOP_SBC_1	0.25
p.E265K	DO41572	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	0.25
p.R270H	TCGA-AX-A2HC	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	0.1111
p.R270H	DO41572	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	0.1111
p.R270H	SIDM00007	Other Solid Cancers	GDSC	VTSST	DEG_SPOP_SBC_1	0.1111
p.R270H	SIDM00209	Glioblastoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.1111
p.R270H	SIDM01490	Small Cell Lung Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.1111
p.I266F	TCGA-EE-A29L	SKCM	TCGA	VTSST	DEG_SPOP_SBC_1	0.2222
p.I266F	DO222599	MELA	ICGC	VTSST	DEG_SPOP_SBC_1	0.2222
p.I266F	DO37835	SKCM	ICGC	VTSST	DEG_SPOP_SBC_1	0.2222
p.P252H	TCGA-NC-A5HQ	LUSC	TCGA	VTSST	DEG_SPOP_SBC_1	0.1667
p.P252H	DO219201	LUSC	ICGC	VTSST	DEG_SPOP_SBC_1	0.1667
p.R270L	TCGA-O2-A52S	LUSC	TCGA	VTSST	DEG_SPOP_SBC_1	0.1111
p.R270L	DO219221	LUSC	ICGC	VTSST	DEG_SPOP_SBC_1	0.1111
p.R270L	SIDM00623	Other Blood Cancers	GDSC	VTSST	DEG_SPOP_SBC_1	0.1111
p.R270L	Mo-T	haematopoietic_and_lymphoid_tissue	COSMIC	VTSST	DEG_SPOP_SBC_1	0.1111
p.A250T	TCGA-VQ-A8PT	STAD	TCGA	VTSST	DEG_SPOP_SBC_1	0.1111
p.A250T	DO234313	ESAD	ICGC	VTSST	DEG_SPOP_SBC_1	0.1111
p.A250T	DO51776	STAD	ICGC	VTSST	DEG_SPOP_SBC_1	0.1111
p.P252S	DO48393	BLCA	ICGC	VTSST	DEG_SPOP_SBC_1	0.1667
p.P252S	DO229010	COCA	ICGC	VTSST	DEG_SPOP_SBC_1	0.1667
p.P252S	DO229003	COCA	ICGC	VTSST	DEG_SPOP_SBC_1	0.1667
p.P252S	DO229346	LAML	ICGC	VTSST	DEG_SPOP_SBC_1	0.1667
p.K259Q	DO228307	BRCA	ICGC	VTSST	DEG_SPOP_SBC_1	0.6944
p.M248I	DO233728	GACA	ICGC	VTSST	DEG_SPOP_SBC_1	0.0556
p.A250S	DO229027	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	0.1111
p.Q261K	DO224563	LUSC	ICGC	VTSST	DEG_SPOP_SBC_1	0.6944
p.R270C	SIDM00933	Breast Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.1111
p.R270C	CAL-51	breast	COSMIC	VTSST	DEG_SPOP_SBC_1	0.1111
p.A256T	SIDM01061	Oral Cavity Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.2778
p.A256T	HN	upper_aerodigestive_tract	COSMIC	VTSST	DEG_SPOP_SBC_1	0.2778
p.R269H	ACH-000256	Ovarian Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	0.1389
p.V267F	NCI-H1993	lung	COSMIC	VTSST	DEG_SPOP_SBC_1	0.1944
p.T248I	RERF-LC-KJ	lung	COSMIC	VTSST	DEG_SPOP_SBC_1	0.0556
p.D265H	NCI-H2009	lung	COSMIC	VTSST	DEG_SPOP_SBC_1	0.25
p.A261T	RF-48	stomach	COSMIC	VTSST	DEG_SPOP_SBC_1	0.7139
p.S248Y	DU-145	prostate	COSMIC	VTSST	DEG_SPOP_SBC_1	0.0556
p.G266S	H513	pleura	COSMIC	VTSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	258:262	VTSST	SPOP	0.8479	More...
P35908	Keratin, type II cytoskeletal 2 epidermal	DEG_SPOP_SBC_1	503:507	VTSST	SPOP	0.842	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	303:307	VTSST	SPOP	0.9985	More...
Q06330	Recombining binding protein suppressor of hairless	DEG_SPOP_SBC_1	491:495	VTSST	SPOP	0.9106	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	1128:1132	VTSST	SPOP	0.8902	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	178:182	VTSST	SPOP	0.8042	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	1479:1483	VTSST	SPOP	0.8438	More...
Q9NPG3	Ubinuclein-1	DEG_SPOP_SBC_1	1001:1005	VTSST	SPOP	0.9937	More...
Q9UJM3	ERBB receptor feedback inhibitor 1	DEG_SPOP_SBC_1	305:309	VTSST	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSST

Degron related mutations and impact score

Drug responses associated with XIRP2 mutations

All proteins holding degron of VTSST