DegronMD - Q5T1M5(FKBP15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1131T	TCGA-13-0903	OV	TCGA	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation altering degron motif	0.6005
p.S1131T	DO32616	OV	ICGC	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation altering degron motif	0.6005
p.Q1119E	TCGA-4Z-AA7R	BLCA	TCGA	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0833
p.Q1119E	DO51866	BLCA	ICGC	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0833
p.V992I	TCGA-AA-3672	COAD	TCGA	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.1667
p.V992I	DO9010	COAD	ICGC	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.1667
p.T1132I	TCGA-AP-A059	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation altering degron motif	0.7078
p.T1132I	DO41361	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation altering degron motif	0.7078
p.P1118R	TCGA-AP-A1DV	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0556
p.P1118R	DO43186	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0556
p.T1000P	TCGA-EO-A22U	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation altering degron motif	0.7031
p.T1000P	DO43755	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation altering degron motif	0.7031
p.P993T	DO228483	BRCA	ICGC	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.1944
p.P993T	DO234285	ESAD	ICGC	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.1944
p.P993T	DO229480	LAML	ICGC	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.1944
p.A998T	DO228035	EOPC	ICGC	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation altering degron motif	0.7139
p.S1131P	DO228542	GACA	ICGC	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation altering degron motif	0.6752
p.S1130R	DO229038	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation altering degron motif	0.7427
p.T1001N	DO229008	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation altering degron motif	0.7055
p.P1118S	SIDM02015	Colorectal Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0556
p.Q1003L	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.3056
p.Q1003L	ACH-000841	Lung Cancer	CCLE	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.3056
p.Q1003L	NCI-H2087	lung	COSMIC	ALTTS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.3056

Kaplan plot for FKBP15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FKBP15

UniProt ID: Q5T1M5

Entrez ID: 23307

Protein name: FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FKBP15 in