DegronMD

Uniprot ID: Q06330

Source protein: Recombining binding protein suppressor of hairless

Source gene: RBPJ

Class: DEG_SPOP_SBC_1

Location: 491:495

E3 ligase: SPOP

DEGRON score: 0.9106

ASA_SCORE: 84.68

COIL: 0.7624

CONS_SCORE: 0.3008

DSS_SCORE: 0.6362

HELIX: 0.0442

FCONS_SCORE: 1.058

RIG_SCORE: 0.6838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S485G	TCGA-B5-A1MX	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	0.1667
p.N487D	TCGA-D1-A17Q	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	0.2222
p.V498A	TCGA-VQ-A8PO	STAD	TCGA	VTSST	DEG_SPOP_SBC_1	0.25
p.A483P	DO229052	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	0.1111
p.V484A	DO51773	STAD	ICGC	VTSST	DEG_SPOP_SBC_1	0.1389
p.T489S	SIDM01015	Chronic Myelogenous Leukemia	GDSC	VTSST	DEG_SPOP_SBC_1	0.2778
p.T489S	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	VTSST	DEG_SPOP_SBC_1	0.2778
p.A484T	SIDM01237	Hepatocellular Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.1389
p.A484T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	258:262	VTSST	SPOP	0.8479	More...
P35908	Keratin, type II cytoskeletal 2 epidermal	DEG_SPOP_SBC_1	503:507	VTSST	SPOP	0.842	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	303:307	VTSST	SPOP	0.9985	More...
Q06330	Recombining binding protein suppressor of hairless	DEG_SPOP_SBC_1	491:495	VTSST	SPOP	0.9106	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	1128:1132	VTSST	SPOP	0.8902	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	178:182	VTSST	SPOP	0.8042	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	1479:1483	VTSST	SPOP	0.8438	More...
Q9NPG3	Ubinuclein-1	DEG_SPOP_SBC_1	1001:1005	VTSST	SPOP	0.9937	More...
Q9UJM3	ERBB receptor feedback inhibitor 1	DEG_SPOP_SBC_1	305:309	VTSST	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons