DegronMD - Q06330(RBPJ)

GO - Biological processes (BP): angiogenesis [GO:0001525]; aortic valve development [GO:0003176]; arterial endothelial cell fate commitment [GO:0060844]; atrioventricular canal development [GO:0036302]; auditory receptor cell fate commitment [GO:0009912]; B cell differentiation [GO:0030183]; blood vessel endothelial cell fate specification [GO:0097101]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; cardiac left ventricle morphogenesis [GO:0003214]; club cell differentiation [GO:0060486]; defense response to bacterium [GO:0042742]; dorsal aorta morphogenesis [GO:0035912]; endocardium morphogenesis [GO:0003160]; epidermal cell fate specification [GO:0009957]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; hair follicle maturation [GO:0048820]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; keratinocyte differentiation [GO:0030216]; labyrinthine layer blood vessel development [GO:0060716]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ossification [GO:0030279]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; pituitary gland development [GO:0021983]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:1901297]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of ephrin receptor signaling pathway [GO:1901189]; positive regulation of ERBB signaling pathway [GO:1901186]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; pulmonary valve development [GO:0003177]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256]; sebaceous gland development [GO:0048733]; secondary heart field specification [GO:0003139]; somatic stem cell population maintenance [GO:0035019]; somitogenesis [GO:0001756]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S485G	TCGA-B5-A1MX	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1667
p.N487D	TCGA-D1-A17Q	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.2222
p.V498A	TCGA-VQ-A8PO	STAD	TCGA	VTSST	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.25
p.A483P	DO229052	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1111
p.V484A	DO51773	STAD	ICGC	VTSST	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1389
p.T489S	SIDM01015	Chronic Myelogenous Leukemia	GDSC	VTSST	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.2778
p.T489S	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	VTSST	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.2778
p.A484T	SIDM01237	Hepatocellular Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1389
p.A484T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBPJ

UniProt ID: Q06330

Entrez ID: 3516

Protein name: Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBPJ in