DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SPOP_SBC_1

Location: 303:307

E3 ligase: SPOP

DEGRON score: 0.9985

ASA_SCORE: 69.34

COIL: 0.7288

CONS_SCORE: 0.5694

DSS_SCORE: 0.3876

HELIX: 0.2248

FCONS_SCORE: 1.151

RIG_SCORE: 0.7204

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G302S	TCGA-AP-A0LM	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	0.3056
p.G302S	DO43306	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	0.3056
p.Q295R	TCGA-DF-A2KU	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	0.1111
p.Q295R	DO223286	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	0.1111
p.A293D	DO229032	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	0.0556
p.S300Y	DO229036	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	0.25
p.T307K	DO229036	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	0.7306
p.Q295K	DO229045	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	0.1111
p.K317R	SIDM02063	Colorectal Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.5
p.K317N	SIDM00193	Colorectal Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.5
p.K317N	ACH-000991	Colon/Colorectal Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	0.5
p.K317N	SNU-81	large_intestine	COSMIC	VTSST	DEG_SPOP_SBC_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	258:262	VTSST	SPOP	0.8479	More...
P35908	Keratin, type II cytoskeletal 2 epidermal	DEG_SPOP_SBC_1	503:507	VTSST	SPOP	0.842	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	303:307	VTSST	SPOP	0.9985	More...
Q06330	Recombining binding protein suppressor of hairless	DEG_SPOP_SBC_1	491:495	VTSST	SPOP	0.9106	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	1128:1132	VTSST	SPOP	0.8902	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	178:182	VTSST	SPOP	0.8042	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	1479:1483	VTSST	SPOP	0.8438	More...
Q9NPG3	Ubinuclein-1	DEG_SPOP_SBC_1	1001:1005	VTSST	SPOP	0.9937	More...
Q9UJM3	ERBB receptor feedback inhibitor 1	DEG_SPOP_SBC_1	305:309	VTSST	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons