DegronMD

Uniprot ID: Q6P0Q8

Source protein: Microtubule-associated serine/threonine-protein kinase 2

Source gene: MAST2

Class: DEG_SCF_FBW7_1

Location: 1637:1642

E3 ligase: FBXW7

DEGRON score: 0.9889

ASA_SCORE: 89

COIL: 0.9468

CONS_SCORE: 0.2056

DSS_SCORE: 0.5969

HELIX: 0.0185

FCONS_SCORE: 0.9682

RIG_SCORE: 0.6253

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1644C	TCGA-58-A46J	LUSC	TCGA	LTPTSS	DEG_SCF_FBW7_1	0.2778
p.S1633I	TCGA-78-8640	LUAD	TCGA	LTPTSS	DEG_SCF_FBW7_1	0.2222
p.S1635L	TCGA-A5-A2K5	UCEC	TCGA	LTPTSS	DEG_SCF_FBW7_1	0.2778
p.T1638N	TCGA-FD-A5BU	BLCA	TCGA	LTPTSS	DEG_SCF_FBW7_1	0.7055
p.L1630I	TCGA-L5-A43J	ESCA	TCGA	LTPTSS	DEG_SCF_FBW7_1	0.1389
p.L1637F	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPTSS	DEG_SCF_FBW7_1	0.6981
p.L1637F	SIDM00722	Mesothelioma	GDSC	LTPTSS	DEG_SCF_FBW7_1	0.6981
p.L1637F	SIDM00923	Cervical Carcinoma	GDSC	LTPTSS	DEG_SCF_FBW7_1	0.6981
p.L1637F	SIDM00057	Neuroblastoma	GDSC	LTPTSS	DEG_SCF_FBW7_1	0.6981
p.L1637F	SIDM01503	Small Cell Lung Carcinoma	GDSC	LTPTSS	DEG_SCF_FBW7_1	0.6981
p.L1637F	SIDM01665	Colorectal Carcinoma	GDSC	LTPTSS	DEG_SCF_FBW7_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SCF_FBW7_1	1637:1642	LTPTSS	FBXW7	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons