DegronMD

Uniprot ID: Q6P0Q8

Source protein: Microtubule-associated serine/threonine-protein kinase 2

Source gene: MAST2

Class: DEG_Kelch_Keap1_1

Location: 1254:1259

E3 ligase: KEAP1

DEGRON score: 0.9967

ASA_SCORE: 87.9833

COIL: 0.9122

CONS_SCORE: 0.3467

DSS_SCORE: 0.6586

HELIX: 0.0437

FCONS_SCORE: 1.0514

RIG_SCORE: 0.5043

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1246C	TCGA-CD-8536	STAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246C	TCGA-F4-6856	COAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.P1262A	TCGA-F4-6570	COAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.25
p.E1250K	DO4012	BRCA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.6667
p.P1252L	DO8119	COAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.2778
p.R1254M	DO18938	KIRC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.8632
p.R1254M	DO37631	SKCM	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.8632
p.S1269F	DO45318	LUAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.P1258F	DO222504	MELA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.7897
p.R1246L	SIDM00608	Plasma Cell Myeloma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM01040	Ovarian Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00491	Thyroid Gland Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00362	Burkitt's Lymphoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00296	Small Cell Lung Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00592	Oral Cavity Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00351	Oral Cavity Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00687	Gastric Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00292	Small Cell Lung Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00294	Small Cell Lung Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00240	Cervical Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM00239	Kidney Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM01447	Glioblastoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.R1246L	SIDM01473	Plasma Cell Myeloma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_Kelch_Keap1_1	1290:1295	SLSSGE	KEAP1	0.9965	More...
P04150	Glucocorticoid receptor	DEG_Kelch_Keap1_1	111:116	SLSSGE	KEAP1	0.6996	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_Kelch_Keap1_1	1254:1259	SLSSGE	KEAP1	0.9967	More...
Q8IY81	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3	DEG_Kelch_Keap1_1	333:338	SLSSGE	KEAP1	0.9727	More...
Q8TDX9	Polycystic kidney disease protein 1-like 1	DEG_Kelch_Keap1_1	1160:1165	SLSSGE	KEAP1	0.6964	More...
Q6P3S6	F-box only protein 42	DEG_Kelch_Keap1_1	592:597	SLSSGE	KEAP1	0.9619	More...
Q96BV0	Zinc finger protein 775	DEG_Kelch_Keap1_1	99:104	SLSSGE	KEAP1	0.7671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SLSSGE

Degron related mutations and impact score

Drug responses associated with MAST2 mutations

All proteins holding degron of SLSSGE