DegronMD

Uniprot ID: Q8IY81

Source protein: pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

Source gene: FTSJ3

Class: DEG_Kelch_Keap1_1

Location: 333:338

E3 ligase: KEAP1

DEGRON score: 0.9727

ASA_SCORE: 87.7667

COIL: 0.892

CONS_SCORE: 0.2963

DSS_SCORE: 0.64

HELIX: 0.0842

FCONS_SCORE: 1.0488

RIG_SCORE: 0.6053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E339D	TCGA-AA-3947	COAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.3056
p.E339D	DO8192	COAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.3056
p.D340A	TCGA-BH-A18G	BRCA	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.2778
p.D340A	DO3686	BRCA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.2778
p.E325D	DO229036	LICA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.T348I	SIDM00971	Breast Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.5
p.T348I	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_Kelch_Keap1_1	1290:1295	SLSSGE	KEAP1	0.9965	More...
P04150	Glucocorticoid receptor	DEG_Kelch_Keap1_1	111:116	SLSSGE	KEAP1	0.6996	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_Kelch_Keap1_1	1254:1259	SLSSGE	KEAP1	0.9967	More...
Q8IY81	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3	DEG_Kelch_Keap1_1	333:338	SLSSGE	KEAP1	0.9727	More...
Q8TDX9	Polycystic kidney disease protein 1-like 1	DEG_Kelch_Keap1_1	1160:1165	SLSSGE	KEAP1	0.6964	More...
Q6P3S6	F-box only protein 42	DEG_Kelch_Keap1_1	592:597	SLSSGE	KEAP1	0.9619	More...
Q96BV0	Zinc finger protein 775	DEG_Kelch_Keap1_1	99:104	SLSSGE	KEAP1	0.7671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons