DegronMD

Uniprot ID: Q96BV0

Source protein: Zinc finger protein 775

Source gene: ZNF775

Class: DEG_Kelch_Keap1_1

Location: 99:104

E3 ligase: KEAP1

DEGRON score: 0.7671

ASA_SCORE: 63.6

COIL: 0.7005

CONS_SCORE: 0.6854

DSS_SCORE: 0.3159

HELIX: 0.0335

FCONS_SCORE: 1.0489

RIG_SCORE: 0.6054

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G105C	TCGA-44-5644	LUAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.3056
p.G105C	DO25153	LUAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.3056
p.S97N	TCGA-Z2-AA3S	SKCM	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.2778
p.S97N	DO51302	SKCM	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.2778
p.G94D	DO222765	COCA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.1944
p.S102A	DO231598	LINC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.7588
p.S102A	DO231553	LINC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.7588
p.G90R	DO232761	PBCA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.0833
p.A92V	SIDM00683	Prostate Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1389
p.A92V	ACH-000977	lymph_node	CCLE	SLSSGE	DEG_Kelch_Keap1_1	0.1389
p.G113R	SIDM00839	Colorectal Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.0833
p.G113R	ACH-000950	Colon/Colorectal Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	0.0833
p.V108A	ACH-000984	Endometrial/Uterine Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	0.2222
p.P89L	ACH-002396	Bone Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.P89L	Sarc9371	bone	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_Kelch_Keap1_1	1290:1295	SLSSGE	KEAP1	0.9965	More...
P04150	Glucocorticoid receptor	DEG_Kelch_Keap1_1	111:116	SLSSGE	KEAP1	0.6996	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_Kelch_Keap1_1	1254:1259	SLSSGE	KEAP1	0.9967	More...
Q8IY81	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3	DEG_Kelch_Keap1_1	333:338	SLSSGE	KEAP1	0.9727	More...
Q8TDX9	Polycystic kidney disease protein 1-like 1	DEG_Kelch_Keap1_1	1160:1165	SLSSGE	KEAP1	0.6964	More...
Q6P3S6	F-box only protein 42	DEG_Kelch_Keap1_1	592:597	SLSSGE	KEAP1	0.9619	More...
Q96BV0	Zinc finger protein 775	DEG_Kelch_Keap1_1	99:104	SLSSGE	KEAP1	0.7671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons