DegronMD

Uniprot ID: P04150

Source protein: Glucocorticoid receptor

Source gene: NR3C1

Class: DEG_Kelch_Keap1_1

Location: 111:116

E3 ligase: KEAP1

DEGRON score: 0.6996

ASA_SCORE: 66.8167

COIL: 0.7927

CONS_SCORE: 0.2985

DSS_SCORE: 0.46

HELIX: 0.1193

FCONS_SCORE: 0.8974

RIG_SCORE: 0.6927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L102P	TCGA-DI-A1BU	UCEC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.0833
p.L102P	DO42023	UCEC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.0833
p.S113F	TCGA-DK-A6B6	BLCA	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.7982
p.S113F	DO48576	BLCA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.7982
p.S114L	TCGA-IR-A3LH	CESC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.7667
p.S114L	DO44381	CESC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.7667
p.D101N	TCGA-S9-A6WD	LGG	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.D101N	DO50194	LGG	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.D101H	TCGA-UY-A9PE	BLCA	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.D101H	DO219043	BLCA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_Kelch_Keap1_1	1290:1295	SLSSGE	KEAP1	0.9965	More...
P04150	Glucocorticoid receptor	DEG_Kelch_Keap1_1	111:116	SLSSGE	KEAP1	0.6996	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_Kelch_Keap1_1	1254:1259	SLSSGE	KEAP1	0.9967	More...
Q8IY81	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3	DEG_Kelch_Keap1_1	333:338	SLSSGE	KEAP1	0.9727	More...
Q8TDX9	Polycystic kidney disease protein 1-like 1	DEG_Kelch_Keap1_1	1160:1165	SLSSGE	KEAP1	0.6964	More...
Q6P3S6	F-box only protein 42	DEG_Kelch_Keap1_1	592:597	SLSSGE	KEAP1	0.9619	More...
Q96BV0	Zinc finger protein 775	DEG_Kelch_Keap1_1	99:104	SLSSGE	KEAP1	0.7671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons