DegronMD

Uniprot ID: Q6P0Q8

Source protein: Microtubule-associated serine/threonine-protein kinase 2

Source gene: MAST2

Class: DEG_APCC_DBOX_1

Location: 469:477

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7205

ASA_SCORE: 68.2111

COIL: 0.4879

CONS_SCORE: 0.4651

DSS_SCORE: 0.491

HELIX: 0.4444

FCONS_SCORE: 1.041

RIG_SCORE: 0.7661

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E475G	TCGA-43-3920	LUSC	TCGA	TRDPLEEMA	DEG_APCC_DBOX_1	0.6087
p.R460C	TCGA-AJ-A3BG	UCEC	TCGA	TRDPLEEMA	DEG_APCC_DBOX_1	0.0833
p.P485A	TCGA-C8-A12T	BRCA	TCGA	TRDPLEEMA	DEG_APCC_DBOX_1	0.1111
p.M476V	TCGA-DD-A1EE	LIHC	TCGA	TRDPLEEMA	DEG_APCC_DBOX_1	0.6097
p.P485S	TCGA-GN-A26C	SKCM	TCGA	TRDPLEEMA	DEG_APCC_DBOX_1	0.1111
p.M470I	DO6088	BRCA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.7618
p.M470I	DO228974	LICA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.7618
p.I473V	DO223144	ESCA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.7076
p.R467H	DO233203	GACA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.2778
p.R467H	DO27985	OV	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.2778
p.K472N	DO228948	LICA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.6918
p.R460L	DO229028	LICA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.0833
p.R460L	DO26502	LUSC	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.0833
p.R460W	DO26250	LUAD	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.0833
p.R460W	DO42673	UCEC	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.0833
p.R481L	DO37491	SKCM	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.2222
p.R481L	DO37916	SKCM	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.2222
p.R467C	DO38887	STAD	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.2778
p.R465W	DO52399	UCEC	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_APCC_DBOX_1	469:477	TRDPLEEMA	APC,CDC20,FZR1	0.7205	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons