DegronMD

Uniprot ID: Q6P0Q8

Source protein: Microtubule-associated serine/threonine-protein kinase 2

Source gene: MAST2

Class: DEG_APCC_DBOX_1

Location: 1091:1099

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7605

ASA_SCORE: 73.5333

COIL: 0.7566

CONS_SCORE: 0.376

DSS_SCORE: 0.5565

HELIX: 0.1953

FCONS_SCORE: 0.9333

RIG_SCORE: 0.6645

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1098F	TCGA-18-3409	LUSC	TCGA	SRDFLPALG	DEG_APCC_DBOX_1	0.6981
p.L1098F	DO26444	LUSC	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	0.6981
p.L1098F	ACH-001610	Brain Cancer	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	0.6981
p.P1104L	TCGA-EO-A22U	UCEC	TCGA	SRDFLPALG	DEG_APCC_DBOX_1	0.1944
p.P1104L	DO43755	UCEC	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	0.1944
p.H1108Y	TCGA-FS-A1ZW	SKCM	TCGA	SRDFLPALG	DEG_APCC_DBOX_1	0.0833
p.H1108Y	DO37519	SKCM	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	0.0833
p.R1086W	TCGA-LN-A49V	ESCA	TCGA	SRDFLPALG	DEG_APCC_DBOX_1	0.1944
p.E1082K	DO48459	BLCA	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	0.0833
p.E1082Q	DO223597	BLCA	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	0.0833
p.K1104R	DO234285	ESAD	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	0.1944
p.V1105L	DO228937	LICA	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	0.1667
p.R1109W	DO27532	LUSC	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	0.0556
p.E1099D	DO50084	OV	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	0.6758
p.P1097A	DO47088	RECA	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	0.7503
p.D1093H	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	0.6577
p.D1093H	ACH-000365	Lymphoma	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	0.6577
p.D1093H	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	SRDFLPALG	DEG_APCC_DBOX_1	0.6577
p.M1101L	SIDM00845	Burkitt's Lymphoma	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	0.2778
p.M1101L	SIDM00461	Acute Myeloid Leukemia	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	0.2778
p.M1101L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	0.2778
p.M1101L	ACH-000786	Lymphoma	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	0.2778
p.M1101L	ACH-000992	Head and Neck Cancer	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	0.2778
p.M1101L	ACH-001067	Brain Cancer	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	0.2778
p.P1090S	SIDM00414	Bladder Carcinoma	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	0.3056
p.P1090S	ACH-000545	Bladder Cancer	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	0.3056
p.P1090S	VM-CUB-1	urinary_tract	COSMIC	SRDFLPALG	DEG_APCC_DBOX_1	0.3056
p.S1091R	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	0.6316
p.S1091R	NCI-H1993	lung	COSMIC	SRDFLPALG	DEG_APCC_DBOX_1	0.6316

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRDFLPALG

Degron related mutations and impact score

Drug responses associated with MAST2 mutations

All proteins holding degron of SRDFLPALG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_APCC_DBOX_1	1091:1099	SRDFLPALG	APC,CDC20,FZR1	0.7605	More...